PMID- 16934270
OWN - NLM
STAT- MEDLINE
DCOM- 20071016
LR  - 20220316
IS  - 0021-9150 (Print)
IS  - 0021-9150 (Linking)
VI  - 193
IP  - 2
DP  - 2007 Aug
TI  - A monocyte chemoattractant protein-1 gene polymorphism is associated with occult 
      ischemia in a high-risk asymptomatic population.
PG  - 366-72
AB  - Monocyte chemoattractant protein-1 (MCP-1) recruits monocytes into 
      atherosclerotic plaques. A single nucleotide polymorphism in the MCP-1 gene 
      promoter (-2578A>G) results in greater production of MCP-1 protein. We examined 
      the association of this polymorphism with occult coronary artery disease (CAD) 
      and its interaction with CAD risk factor burden, as assessed by the Framingham 
      risk score (FRS) for hard events. We genotyped 679 apparently healthy 
      24-59-year-old siblings (SIBS) of people with premature CAD, tested for occult 
      ischemia with exercise treadmill tests and thallium-201 single photon emission 
      computed tomography, and assessed CAD risk factors to calculate the FRS. Occult 
      ischemia occurred in 18% of SIBS and overall was somewhat more prevalent in those 
      with the G allele (20.6%) compared to those without (15.6%), p=0.095. In SIBS at 
      higher risk (highest quartile of FRS, >or=6.8%), occult ischemia occurred 
      significantly more frequently in those with the G allele (44.4% versus 26.1%, 
      p=0.017), while there was no significant difference in SIBS with lower FRS. After 
      adjusting for individual risk factors included in the FRS, multivariate logistic 
      regression modeling demonstrated that the G allele independently predicted occult 
      ischemia in the entire study population (p=0.014, OR=1.86, 95% CI=1.14-3.04). 
      This study demonstrates for the first time that the MCP-1 gene -2578A>G 
      polymorphism is associated with an excess risk of coronary atherosclerosis in an 
      asymptomatic population and demonstrates an apparent interaction with CAD risk 
      factor burden.
FAU - Kim, Min P
AU  - Kim MP
AD  - Immunopathology Section, National Institute of Dental and Craniofacial Research, 
      USA.
FAU - Wahl, Larry M
AU  - Wahl LM
FAU - Yanek, Lisa R
AU  - Yanek LR
FAU - Becker, Diane M
AU  - Becker DM
FAU - Becker, Lewis C
AU  - Becker LC
LA  - eng
GR  - HL 58625/HL/NHLBI NIH HHS/United States
GR  - HL 59684/HL/NHLBI NIH HHS/United States
GR  - M01-RR000052/RR/NCRR NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20060824
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/blood/*genetics
MH  - Coronary Artery Disease/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*genetics
MH  - Polymorphism, Genetic
MH  - Risk Factors
MH  - Siblings
EDAT- 2006/08/29 09:00
MHDA- 2007/10/17 09:00
CRDT- 2006/08/29 09:00
PHST- 2005/11/02 00:00 [received]
PHST- 2006/04/27 00:00 [revised]
PHST- 2006/06/25 00:00 [accepted]
PHST- 2006/08/29 09:00 [pubmed]
PHST- 2007/10/17 09:00 [medline]
PHST- 2006/08/29 09:00 [entrez]
AID - S0021-9150(06)00395-9 [pii]
AID - 10.1016/j.atherosclerosis.2006.06.029 [doi]
PST - ppublish
SO  - Atherosclerosis. 2007 Aug;193(2):366-72. doi: 
      10.1016/j.atherosclerosis.2006.06.029. Epub 2006 Aug 24.