PMID- 16936757
OWN - NLM
STAT- MEDLINE
DCOM- 20060928
LR  - 20100412
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 25
IP  - 38
DP  - 2006 Aug 28
TI  - Mortality from second tumour among long-term survivors of retinoblastoma: a 
      retrospective analysis of the Italian retinoblastoma registry.
PG  - 5350-7
AB  - Survivors of retinoblastoma (Rb) are at high risk of dying from second malignant 
      tumour. The occurrence of second malignant neoplasm (SMN) and related mortality 
      in a cohort of 1111 cases from the Italian Retinoblastoma Registry was analysed, 
      considering the possible role of both genetic and iatrogenic causes. Rb patients 
      had a greater than 10-fold excess in overall mortality compared with the general 
      population (standardized mortality ratio (SMR) 10.73, 95% CI 9.00-12.80). Their 
      excess risk attributable to cancers other than Rb was 14.93 95% CI 10.38-21.49). 
      Survivors of hereditary Rb had an SMR for all causes of 16.25 (95% CI 
      13.20-20.00), whereas their SMR for all cancers was 25.72 (95% CI 17.38-38.07). 
      Survivors of unilateral sporadic Rb had an SMR of 4.12 from all cancers (95% CI 
      1.55-10.98) and a much higher excess for overall mortality (SMR 13.34, 95% CI 
      10.74-16.56). As expected, survivors of hereditary Rb had higher mortality from 
      cancers of the bone (SMR 391.90, 95% CI 203.90-753.20) and soft tissue (SMR 
      453.00, 95% CI 203.50-1008.40), small intestine (SMR 1375.50, 95% CI 
      344.00-5499.70), nasal cavity (SMR 13.71, 95% CI 1.93-97.35) and cancers of the 
      brain and central nervous system (SMR 41.14, 95% CI 13.2-127.55).
FAU - Acquaviva, A
AU  - Acquaviva A
AD  - Italian Retinoblastoma Registry, Department of Pediatrics, Obstetrics and 
      Reproductive Medicine, University of Siena, Siena, Italy. acquaviva@unisi.it
FAU - Ciccolallo, L
AU  - Ciccolallo L
FAU - Rondelli, R
AU  - Rondelli R
FAU - Balistreri, A
AU  - Balistreri A
FAU - Ancarola, R
AU  - Ancarola R
FAU - Cozza, R
AU  - Cozza R
FAU - Hadjistilianou, D
AU  - Hadjistilianou D
FAU - Francesco, S De
AU  - Francesco SD
FAU - Toti, P
AU  - Toti P
FAU - Pastore, G
AU  - Pastore G
FAU - Haupt, R
AU  - Haupt R
FAU - Carli, M
AU  - Carli M
FAU - Santoro, N
AU  - Santoro N
FAU - Di Cataldo, A
AU  - Di Cataldo A
FAU - Fiorillo, A
AU  - Fiorillo A
FAU - Indolfi, P
AU  - Indolfi P
FAU - Nucci, P
AU  - Nucci P
FAU - Sandri, A
AU  - Sandri A
FAU - Porta, F
AU  - Porta F
FAU - Porcaro, A B
AU  - Porcaro AB
FAU - Tamaro, P
AU  - Tamaro P
FAU - Morgese, G
AU  - Morgese G
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
SB  - IM
MH  - Cohort Studies
MH  - Functional Laterality
MH  - Germ-Line Mutation
MH  - Humans
MH  - Italy
MH  - Neoplasms, Second Primary/*mortality
MH  - Registries
MH  - Retinal Neoplasms/genetics/*pathology
MH  - Retinoblastoma/genetics/*pathology
MH  - Survival Analysis
MH  - Survivors
EDAT- 2006/08/29 09:00
MHDA- 2006/09/29 09:00
CRDT- 2006/08/29 09:00
PHST- 2006/08/29 09:00 [pubmed]
PHST- 2006/09/29 09:00 [medline]
PHST- 2006/08/29 09:00 [entrez]
AID - 1209786 [pii]
AID - 10.1038/sj.onc.1209786 [doi]
PST - ppublish
SO  - Oncogene. 2006 Aug 28;25(38):5350-7. doi: 10.1038/sj.onc.1209786.