PMID- 16938565
OWN - NLM
STAT- MEDLINE
DCOM- 20061030
LR  - 20061115
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 169
IP  - 2
DP  - 2006 Sep
TI  - Relation of glutathione S-transferase genotypes (GSTM1 and GSTT1) to laryngeal 
      squamous cell carcinoma risk.
PG  - 89-93
AB  - The purpose of the present study was to investigate GSTM1 and GSTT1 genotypes by 
      using multiplex polymerase chain reaction (PCR) in patients with laryngeal 
      squamous cell carcinoma (LSCC). The genotypes of 110 patients with LSCC and of 
      197 healthy subjects as the control group were determined by PCR analysis for 
      GSTM1 and GSTT1 genes. Results showed that frequencies of GSTM1-null, GSTT1-null, 
      and both GSTs-null genotypes were 51.8, 30, and 16.4%, respectively, in the 
      patients with LSCC and 37.6, 15.7, and 5.6% in the control group. There was a 
      significant difference between the genotype distributions of all GSTs in patients 
      and in control groups (P < 0.05). The results support the hypothesis that null 
      genotypes of GSTM1 and GSTT1 can reduce detoxification capacity of GSTs as 
      members of the xenobiotic enzyme system. GSTM1-null, GSTT1-null, and both 
      GSTs-null genotypes were more common in the patients with LSCC than in the 
      control group. Patients with both GSTs-null genotypes had the highest risk for 
      supraglottic LSCC in the early period, even if they were light-to-medium smokers. 
      Investigation and determination of the genetic basis of LSCC may contribute to 
      detection of risk groups and to prevent LSCC in the population.
FAU - Acar, Hasan
AU  - Acar H
AD  - Department of Medical Genetics, Selcuk University, Meram Medical Faculty, Vali 
      Izzet Pasa Caddesi, Konya 42090, Turkey. yaseminsena@hotmail.com
FAU - Ozturk, Kayhan
AU  - Ozturk K
FAU - Muslumanoglu, M Hamza
AU  - Muslumanoglu MH
FAU - Yildirim, M Selman
AU  - Yildirim MS
FAU - Cora, Tulin
AU  - Cora T
FAU - Cilingir, Oguz
AU  - Cilingir O
FAU - Ozer, Bedri
AU  - Ozer B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - EC 2.5.1.- (glutathione S-transferase T1)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - EC 2.5.1.18 (glutathione S-transferase M1)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Alcohol Drinking/adverse effects
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Case-Control Studies
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Glutathione Transferase/*genetics
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Risk Factors
MH  - Smoking/adverse effects
EDAT- 2006/08/30 09:00
MHDA- 2006/10/31 09:00
CRDT- 2006/08/30 09:00
PHST- 2005/11/24 00:00 [received]
PHST- 2005/12/01 00:00 [revised]
PHST- 2005/12/14 00:00 [accepted]
PHST- 2006/08/30 09:00 [pubmed]
PHST- 2006/10/31 09:00 [medline]
PHST- 2006/08/30 09:00 [entrez]
AID - S0165-4608(05)00740-5 [pii]
AID - 10.1016/j.cancergencyto.2005.12.007 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2006 Sep;169(2):89-93. doi: 
      10.1016/j.cancergencyto.2005.12.007.