PMID- 1693942
OWN - NLM
STAT- MEDLINE
DCOM- 19900724
LR  - 20190510
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 162
IP  - 1
DP  - 1990 Jul
TI  - Interferon induction by human herpesvirus 6 in human mononuclear cells.
PG  - 35-8
AB  - Interferon (IFN) production after inoculation with human herpesvirus 6 (HHV-6) 
      was studied in peripheral blood mononuclear cells from 10 HHV-6-seropositive 
      healthy adults and five samples of cord blood mononuclear cells. When the cells 
      were exposed to HHV-6 at a multiplicity of infection of 10(-2) 50% tissue culture 
      infectious doses/cell, IFN activity was detected as early as 12 h after exposure 
      to HHV-6, plateaued at days 2-5, and gradually decreased thereafter. IFN was also 
      induced by ultraviolet-inactivated but not heat-inactivated HHV-6. The response 
      of cord blood mononuclear cells was lower than that of the cells from healthy 
      adults. The activity of all IFN samples was stable to acid and exclusively 
      neutralized by anti-human IFN-alpha. The IFN-producing cell population was mainly 
      non-T cells and monocytes. Furthermore, exogenous IFN suppressed HHV-6 
      replication. Production of IFN-alpha may be an important part of the host 
      response to HHV-6.
FAU - Kikuta, H
AU  - Kikuta H
AD  - Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan.
FAU - Nakane, A
AU  - Nakane A
FAU - Lu, H
AU  - Lu H
FAU - Taguchi, Y
AU  - Taguchi Y
FAU - Minagawa, T
AU  - Minagawa T
FAU - Matsumoto, S
AU  - Matsumoto S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Interferon Type I)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Cell Separation
MH  - Cells, Cultured
MH  - Fetal Blood/cytology
MH  - Herpesvirus 6, Human/*immunology
MH  - Humans
MH  - Interferon Type I/biosynthesis
MH  - Interferons/*biosynthesis
MH  - Kinetics
MH  - Leukocytes, Mononuclear/*immunology/microbiology
MH  - Monocytes/immunology
EDAT- 1990/07/01 00:00
MHDA- 1990/07/01 00:01
CRDT- 1990/07/01 00:00
PHST- 1990/07/01 00:00 [pubmed]
PHST- 1990/07/01 00:01 [medline]
PHST- 1990/07/01 00:00 [entrez]
AID - 10.1093/infdis/162.1.35 [doi]
PST - ppublish
SO  - J Infect Dis. 1990 Jul;162(1):35-8. doi: 10.1093/infdis/162.1.35.