PMID- 16941154
OWN - NLM
STAT- MEDLINE
DCOM- 20070104
LR  - 20181113
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 449
IP  - 4
DP  - 2006 Oct
TI  - Prognostic value of the International Neuroblastoma Pathology Classification in 
      Neuroblastoma (Schwannian stroma-poor) and comparison with other prognostic 
      factors: a study of 182 cases from the Spanish Neuroblastoma Registry.
PG  - 410-20
AB  - In addition to clinical and biological factors, further valuable prognostic 
      information in neuroblastoma (Schwannian stroma-poor) (NB) patients is provided 
      by the histopathologic analysis and the application of the International 
      Neuroblastoma Pathology Classification (INPC) system. The objective of this study 
      was to assess the prognostic impact of the INPC classification in a series of NB 
      (Schwannian stroma-poor) and its relation with other prognostic factors. One 
      hundred eighty-two cases of NB were collected from the files of the Spanish 
      Neuroblastoma Registry. Slides were reviewed, and NB cases were grouped into 
      favorable and unfavorable categories according to INPC criteria, taking into 
      account morphological features (mitosis-karyorrhexis index, histological subtype) 
      and patient's age at diagnosis. Other pathological [presence of calcifications, 
      tissular components, and number of mitotic cells per 10 high-power field (HPF)], 
      immunohistochemical (P-glycoprotein and Ki-67 protein expression) and genetic 
      (MYCN amplification and chromosome 1p deletion) features were also studied. 
      Statistical analyses of overall survival with Kaplan-Meier curves and a 
      multivariate study using Cox regression were performed (40.3% of NBs were 
      considered favorable and 59.7% unfavorable). Unfavorable NB showed a mean 
      survival time of 57 months compared with 89 months in favorable cases. Advanced 
      stage, more than ten mitoses per 10 HPF, Ki-67 expression in more than 30% of 
      tumor cells, MYCN oncogene amplification and chromosome 1p deletion were observed 
      more frequently in unfavorable NB. The Cox regression analysis demonstrated that 
      clinical stage (International Neuroblastoma Staging System stage 4) and 
      histological subtype (undifferentiated NB) were the most important factors that 
      influence the overall survival (p<0.001). INPC classification results are major 
      prognostic indicators in NB and should be considered in the therapeutic 
      stratification of NB patients.
FAU - Burgues, Octavio
AU  - Burgues O
AD  - Departamento de Patologia, Facultad de Medicina de Valencia, Avda. Blasco Ibanez, 
      17, E-46010, Pediatric Oncology Unit, Hospital Universitario La Fe, Valencia, 
      Spain.
FAU - Navarro, Samuel
AU  - Navarro S
FAU - Noguera, Rosa
AU  - Noguera R
FAU - Pellin, Antonio
AU  - Pellin A
FAU - Ruiz, Amparo
AU  - Ruiz A
FAU - Castel, Victoria
AU  - Castel V
FAU - Llombart-Bosch, Antonio
AU  - Llombart-Bosch A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060829
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gene Amplification
MH  - Humans
MH  - Infant
MH  - International Cooperation
MH  - Male
MH  - Mitosis
MH  - Neuroblastoma/*classification/genetics/mortality
MH  - Peripheral Nervous System Neoplasms/*classification/genetics/mortality
MH  - Prognosis
MH  - Risk Factors
MH  - Schwann Cells/pathology
MH  - Spain/epidemiology
MH  - Survival Rate
EDAT- 2006/08/31 09:00
MHDA- 2007/01/05 09:00
CRDT- 2006/08/31 09:00
PHST- 2005/12/21 00:00 [received]
PHST- 2006/06/13 00:00 [accepted]
PHST- 2006/08/31 09:00 [pubmed]
PHST- 2007/01/05 09:00 [medline]
PHST- 2006/08/31 09:00 [entrez]
AID - 10.1007/s00428-006-0253-y [doi]
PST - ppublish
SO  - Virchows Arch. 2006 Oct;449(4):410-20. doi: 10.1007/s00428-006-0253-y. Epub 2006 
      Aug 29.