PMID- 16941223
OWN - NLM
STAT- MEDLINE
DCOM- 20070517
LR  - 20181113
IS  - 1569-5794 (Print)
IS  - 1569-5794 (Linking)
VI  - 23
IP  - 2
DP  - 2007 Apr
TI  - Plasma natriuretic peptide levels reflect changes in heart failure symptoms, left 
      ventricular size and function after surgical mitral valve repair.
PG  - 159-65
AB  - BACKGROUND AND AIM: N-terminal pro-B-type natriuretic peptide (NT-proBNP) has 
      diagnostic and prognostic value in patients with heart failure. The present 
      prospective study was designed to assess whether changes in NT-proBNP levels 
      after surgical mitral valve repair reflect changes in heart failure symptoms and 
      changes in left atrial size, left ventricular size and left ventricular function. 
      METHODS: The study population consisted of 22 patients (mean age: 62.8 +/- 14.2 
      years, 68% male) undergoing surgical mitral valve repair. Serial NT-proBNP 
      measurements, transthoracic echocardiography and New York Heart Association 
      (NYHA) class assessment were performed before and 6 months after surgery. 
      RESULTS: All patients underwent successful mitral valve repair and no patients 
      died during follow-up. The decrease in NT-proBNP level was associated with the 
      reduction in left atrial dimension (r = 0.72, P < 0.001), left ventricular 
      end-systolic dimension (r = 0.63, P = 0.002), left ventricular end-diastolic 
      dimension (r = 0.46, P = 0.031), and the increase in fractional shortening (r = - 
      0.63, P = 0.002). Finally, patients with decreasing NT-proBNP levels revealed a 
      significant improvement in heart failure symptoms (NYHA class). CONCLUSION: 
      Changes in NT-proBNP after surgical mitral valve repair reflect changes in heart 
      failure symptoms and changes in left atrial and ventricular dimensions and 
      function.
FAU - Feringa, Harm H H
AU  - Feringa HH
AD  - Department of Cardiothoracic Surgery/Cardiology, C-5, Leiden University Medical 
      Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. h.feringa@erasmusmc.nl
FAU - Poldermans, Don
AU  - Poldermans D
FAU - Klein, Patrick
AU  - Klein P
FAU - Braun, Jerry
AU  - Braun J
FAU - Klautz, Robert J M
AU  - Klautz RJ
FAU - van Domburg, Ron T
AU  - van Domburg RT
FAU - van der Laarse, Arnoud
AU  - van der Laarse A
FAU - van der Wall, Ernst E
AU  - van der Wall EE
FAU - Dion, Robert A E
AU  - Dion RA
FAU - Bax, Jeroen J
AU  - Bax JJ
LA  - eng
PT  - Journal Article
DEP - 20060829
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Diastole
MH  - Echocardiography, Transesophageal
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Atria/diagnostic imaging
MH  - Heart Failure/*blood/etiology/pathology/*physiopathology/surgery
MH  - Heart Ventricles/diagnostic imaging
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/*surgery
MH  - Mitral Valve Insufficiency/blood/complications/physiopathology/*surgery
MH  - Myocardial Contraction
MH  - Natriuretic Peptide, Brain/*blood
MH  - Organ Size
MH  - Peptide Fragments/*blood
MH  - Prognosis
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Systole
MH  - Time Factors
MH  - Treatment Outcome
MH  - *Ventricular Function, Left
MH  - Ventricular Remodeling
EDAT- 2006/08/31 09:00
MHDA- 2007/05/18 09:00
CRDT- 2006/08/31 09:00
PHST- 2006/06/07 00:00 [received]
PHST- 2006/07/15 00:00 [accepted]
PHST- 2006/08/31 09:00 [pubmed]
PHST- 2007/05/18 09:00 [medline]
PHST- 2006/08/31 09:00 [entrez]
AID - 10.1007/s10554-006-9138-z [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2007 Apr;23(2):159-65. doi: 10.1007/s10554-006-9138-z. 
      Epub 2006 Aug 29.