PMID- 16941231
OWN - NLM
STAT- MEDLINE
DCOM- 20070329
LR  - 20220716
IS  - 0364-3190 (Print)
IS  - 0364-3190 (Linking)
VI  - 31
IP  - 9
DP  - 2006 Sep
TI  - Changes in amino acids and nitric oxide concentration in cerebrospinal fluid 
      during labor pain.
PG  - 1127-33
AB  - This study analyzes the relationship between amino acids and pain perception 
      during active labor. Cerebrospinal fluid (CSF) levels of the excitatory amino 
      acids (EAAs)-glutamate, aspartate and their amide forms, inhibitory amino acids 
      (IAAs)-glycine, gamma-amino butyric acid (GABA) and taurine and nitric oxide (NO) 
      related compounds-arginine and citrulline (by-product of NO synthesis) were 
      compared between pregnant women at term pregnancy with labor pain (n = 38) and 
      without labor pain (Caesarian section; n = 30). The levels of aspartate, glycine, 
      GABA and citrulline were significantly higher; whilst taurine was significantly 
      lower in the labor pain group. These findings suggest that aspartate and NO are 
      associated with labor pain. An inhibitory role for the IAA taurine and a 
      pronociceptive role for glycine in labor pain are proposed.
FAU - Sethuraman, Rama
AU  - Sethuraman R
AD  - Department of Anaesthesia, National University of Singapore, 5 Lower Kent Ridge 
      Road, Singapore, 119074, Singapore. anast@nus.edu.sg
FAU - Lee, Tat-Leang
AU  - Lee TL
FAU - Chui, Jen-Wun
AU  - Chui JW
FAU - Tachibana, Shinro
AU  - Tachibana S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060829
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Amino Acids)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Amino Acids/*cerebrospinal fluid
MH  - Female
MH  - Humans
MH  - Labor Pain/*cerebrospinal fluid
MH  - Nitric Oxide/*cerebrospinal fluid
MH  - Pregnancy
EDAT- 2006/08/31 09:00
MHDA- 2007/03/30 09:00
CRDT- 2006/08/31 09:00
PHST- 2006/08/01 00:00 [accepted]
PHST- 2006/08/31 09:00 [pubmed]
PHST- 2007/03/30 09:00 [medline]
PHST- 2006/08/31 09:00 [entrez]
AID - 10.1007/s11064-006-9133-8 [doi]
PST - ppublish
SO  - Neurochem Res. 2006 Sep;31(9):1127-33. doi: 10.1007/s11064-006-9133-8. Epub 2006 
      Aug 29.