PMID- 16941276
OWN - NLM
STAT- MEDLINE
DCOM- 20061019
LR  - 20220409
IS  - 0018-5043 (Print)
IS  - 0018-5043 (Linking)
VI  - 38
IP  - 8
DP  - 2006 Aug
TI  - IL-18: relationship with anthropometry, body composition parameters, leptin and 
      arterial hypertension.
PG  - 507-12
AB  - OBJECTIVE: Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine with 
      potential atherogenic properties whose role in human obesity has been recently 
      suggested. The aim of our study was to analyze the physiologic distribution of 
      IL-18 among sexes and all decades of the adult life in a healthy population 
      randomly selected and to study its relationship with anthropometric, body 
      composition measurements and leptin concentrations. We also studied the 
      relationship of IL-18 with smoking and arterial hypertension, known risk factors 
      implicated in atherogenesis. MATERIALS AND METHODS: One hundred and thirty four 
      men and 127 healthy women were included in the study. Plasma concentrations of 
      IL-18 and leptin were determined in all subjects. Body composition was evaluated 
      by bioelectrical impedanciometry. RESULTS: IL-18 was distributed similarly in men 
      and women and throughout decades. No significant differences were found in IL-18 
      between obese and normal-weight men and women according to their body mass index 
      and body fat content. Higher IL-18 concentrations were found in subjects with 
      arterial hypertension. In the bivariate correlation analysis only waist to hip 
      ratio correlated weakly with IL-18 in the whole population (r=0.12, p=0.04). In 
      the multiple regression analysis the relationship between IL-18 and waist to hip 
      ratio lost significance after adjusting for age, sex and body mass index. 
      However, IL-18 remained associated with arterial hypertension (adjusted r2=0.25, 
      p=0.023). CONCLUSIONS: The lack of correlation between IL-18 with anthropometric, 
      body composition variables and leptin in our healthy population argues against a 
      role of this cytokine in obesity. Moreover, our findings suggest the implication 
      of this interleukin in the atherogenic process induced by arterial hypertension.
FAU - Vilarrasa, N
AU  - Vilarrasa N
AD  - Endocrinology and Diabetes Unit, Hospital Universitari de Bellvitge, Barcelona, 
      Spain. nuriavilarrasa@yahoo.es
FAU - Vendrell, J
AU  - Vendrell J
FAU - Maravall, J
AU  - Maravall J
FAU - Broch, M
AU  - Broch M
FAU - Estepa, A
AU  - Estepa A
FAU - Megia, A
AU  - Megia A
FAU - Soler, J
AU  - Soler J
FAU - Simon, I
AU  - Simon I
FAU - Richart, C
AU  - Richart C
FAU - Gomez, J M
AU  - Gomez JM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Interleukin-18)
RN  - 0 (Leptin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Anthropometry
MH  - *Body Composition
MH  - Body Mass Index
MH  - Female
MH  - Humans
MH  - Hypertension/*blood/pathology
MH  - Interleukin-18/*blood
MH  - Leptin/*blood
MH  - Male
MH  - Middle Aged
MH  - Waist-Hip Ratio
EDAT- 2006/08/31 09:00
MHDA- 2006/10/20 09:00
CRDT- 2006/08/31 09:00
PHST- 2006/08/31 09:00 [pubmed]
PHST- 2006/10/20 09:00 [medline]
PHST- 2006/08/31 09:00 [entrez]
AID - 10.1055/s-2006-949122 [doi]
PST - ppublish
SO  - Horm Metab Res. 2006 Aug;38(8):507-12. doi: 10.1055/s-2006-949122.