PMID- 16946516
OWN - NLM
STAT- MEDLINE
DCOM- 20061005
LR  - 20190720
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 29
IP  - 9
DP  - 2006 Sep
TI  - Responses of the liver to perfluorinated fatty acids with different carbon chain 
      length in male and female mice:in relation to induction of hepatomegaly, 
      peroxisomal beta-oxidation and microsomal 1-acylglycerophosphocholine 
      acyltransferase.
PG  - 1952-7
AB  - The potency of the induction of hepatomegaly, peroxisomal beta-oxidation and 
      microsomal 1-acylglycerophoshocholine (1-acyl-GPC) acyltransferase was compared 
      among perfluorinated fatty acids (PFCAs) with 6-9 carbon chain length in the 
      liver of male and female mice. All PFCAs examined induced hepatomegaly and 
      peroxisomal beta-oxidation and the potency was in the order of perfluorononanonic 
      acid (PFNA), perfluorooctanoic acid (PFOA), perfluoroheptanoic acid (PFHA) and 
      perfluorohexanoic acid (PFHeA) when compared with the relative doses to induce 
      the two parameters. Microsomal 1-acyl-GPC acyltransferase was induced by PFHA, 
      PFOA and PFNA, as was peroxisomal beta-oxidation. No significant sex-related 
      difference was observed in the induction of peroxisomal beta-oxidation by any 
      PFCAs examined. PFNA and PFOA accumulated in the liver of both male and female 
      mice in a dose-dependent manner. PFHA accumulated in the liver to a lesser 
      extent; little PFHeA accumulated in the liver. Hepatic concentrations of PFNA, 
      PFOA and PFHA were higher in male mice than those in female mice. One linear 
      regression line was confirmed between the activities of peroxisomal 
      beta-oxidation and hepatic concentrations of PFHeA, PFHA, PFOA and PFNA in male 
      mice regardless of their carbon chain lengths, and the activities were saturable 
      at the concentrations over approximately 500 nmol/g liver. Similar linear 
      regression line was obtained between the two parameters in female mice. These 
      results suggest (i) that the longer the perfluoroalkyl chain becomes, the more 
      PFCA accumulates in the liver of both male and female mice, (ii) that the 
      accumulated PFCAs induce hepatomegaly, peroxisomal beta-oxidation and microsomal 
      1-acyl-GPC acyltransferase, and (iii) that the difference observed in the 
      accumulation of PFHA, PFOA and PFNA in the liver between male and female mice is 
      not enough to produce obvious sex-related difference in the induction of 
      peroxisomal beta-oxidation.
FAU - Kudo, Naomi
AU  - Kudo N
AD  - Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama, Japan. 
      naokudo@josai.ac.jp
FAU - Suzuki-Nakajima, Erika
AU  - Suzuki-Nakajima E
FAU - Mitsumoto, Atsushi
AU  - Mitsumoto A
FAU - Kawashima, Yoichi
AU  - Kawashima Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Caproates)
RN  - 0 (Caprylates)
RN  - 0 (Fluorocarbons)
RN  - 76-21-1 (hexadecafluoro-nonanoic acid)
RN  - 947VD76D3L (perfluorooctanoic acid)
RN  - EC 2.3.1.23 (1-Acylglycerophosphocholine O-Acyltransferase)
RN  - ZP34Q2220R (perfluorohexanoic acid)
SB  - IM
MH  - 1-Acylglycerophosphocholine O-Acyltransferase/*metabolism
MH  - Animals
MH  - Body Weight/drug effects
MH  - Caproates/pharmacokinetics/*toxicity
MH  - Caprylates/pharmacokinetics/*toxicity
MH  - Female
MH  - Fluorocarbons/pharmacokinetics/*toxicity
MH  - Hepatomegaly/*chemically induced
MH  - Liver/*drug effects
MH  - Male
MH  - Mice
MH  - Microsomes, Liver/enzymology
MH  - Organ Size/drug effects
MH  - Oxidation-Reduction
MH  - Peroxisomes/*drug effects/metabolism
MH  - Sex Characteristics
MH  - Structure-Activity Relationship
EDAT- 2006/09/02 09:00
MHDA- 2006/10/06 09:00
CRDT- 2006/09/02 09:00
PHST- 2006/09/02 09:00 [pubmed]
PHST- 2006/10/06 09:00 [medline]
PHST- 2006/09/02 09:00 [entrez]
AID - JST.JSTAGE/bpb/29.1952 [pii]
AID - 10.1248/bpb.29.1952 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2006 Sep;29(9):1952-7. doi: 10.1248/bpb.29.1952.