PMID- 16946537
OWN - NLM
STAT- MEDLINE
DCOM- 20061016
LR  - 20190706
IS  - 0009-2363 (Print)
IS  - 0009-2363 (Linking)
VI  - 54
IP  - 9
DP  - 2006 Sep
TI  - Bitterness suppression of BCAA solutions by L-ornithine.
PG  - 1288-92
AB  - The purpose of the present study was to evaluate the bitterness-suppressing 
      effect of L-ornithine (L-Orn) on single or mixed solutions of branched-chain 
      amino acids (BCAAs) using human gustatory sensation tests and an artificial taste 
      sensor. The BCAAs tested (L-isoleucine (L-Ile), L-leucine (L-Leu), and L-valine 
      (L-Val)) are the main components of various enteral nutrients or supplements. The 
      bitterness-suppression effect of L-Orn was also compared with the effect of 
      L-Arg. L-Orn was effective in suppressing the bitterness of single or mixed 
      solutions of BCAAs in human gustatory sensation tests, the effect being similar 
      to or greater than that of L-Arg. The artificial taste sensor was able to predict 
      the bitterness-suppressing effects of L-Orn and L-Arg. The response electric 
      potential patterns of L-Val, L-Leu and L-Ile solutions to which 100 mM L-Arg had 
      been added were quite similar to the sensor response patterns of the 100 mM L-Arg 
      solutions alone. The relative response electric potential patterns of L-Val, 
      L-Leu or L-Ile solutions containing 100 mM L-Orn in channels 5-8 (positively 
      charged) are similar to that of single solution of 100 mM L-Orn.
FAU - Tokuyama, Emi
AU  - Tokuyama E
AD  - School of Pharmaceutical Science, Mukogawa Women's University, 11-68 Koshien, 
      9-Bancho, Nishinomiya, Hyogo 663-8179, Japan.
FAU - Shibasaki, Takeshi
AU  - Shibasaki T
FAU - Kawabe, Hideo
AU  - Kawabe H
FAU - Mukai, Junji
AU  - Mukai J
FAU - Okada, Sachie
AU  - Okada S
FAU - Uchida, Takahiro
AU  - Uchida T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Chem Pharm Bull (Tokyo)
JT  - Chemical & pharmaceutical bulletin
JID - 0377775
RN  - 0 (Amino Acids, Branched-Chain)
RN  - 0 (Solutions)
RN  - 94ZLA3W45F (Arginine)
RN  - A7V27PHC7A (Quinine)
RN  - E524N2IXA3 (Ornithine)
SB  - IM
MH  - Amino Acids, Branched-Chain/*chemistry
MH  - Arginine/chemistry
MH  - Humans
MH  - Ornithine/*chemistry/pharmacology
MH  - Quinine/chemistry/metabolism
MH  - Sensitivity and Specificity
MH  - Solutions/chemistry
MH  - *Taste/drug effects
EDAT- 2006/09/02 09:00
MHDA- 2006/10/17 09:00
CRDT- 2006/09/02 09:00
PHST- 2006/09/02 09:00 [pubmed]
PHST- 2006/10/17 09:00 [medline]
PHST- 2006/09/02 09:00 [entrez]
AID - JST.JSTAGE/cpb/54.1288 [pii]
AID - 10.1248/cpb.54.1288 [doi]
PST - ppublish
SO  - Chem Pharm Bull (Tokyo). 2006 Sep;54(9):1288-92. doi: 10.1248/cpb.54.1288.