PMID- 16946758
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20181201
IS  - 0950-222X (Print)
IS  - 0950-222X (Linking)
VI  - 22
IP  - 2
DP  - 2008 Feb
TI  - Comparison of visual acuity outcomes in predominantly classic vs occult lesions 
      in age-related macular degeneration treated with photodynamic therapy.
PG  - 194-9
AB  - PURPOSE: To determine if patients with occult with no classic and predominantly 
      classic (PC) choroidal neovascular membranes have clinically equivalent visual 
      outcomes after treatment with photodynamic therapy (PDT) with verteporfin. 
      METHODS: This is a retrospective, observational cohort study. Two hundred and 
      seventy-seven consecutive patients with occult or PC choroidal neovascularization 
      secondary to age-related macular degeneration treated with PDT were included. The 
      main outcome was the difference in mean change in Early Treatment of Diabetic 
      Retinopathy Study (ETDRS) acuity lost from baseline in occult vs PC lesions, with 
      the minimal clinically important difference (MCID) set at 7.5 letters. RESULTS: 
      At baseline, 131 patients had occult and 146 had PC choroidal neovascularization. 
      Twelve-month follow-up data were available for 94 occult and 110 PC participants. 
      Occult patients lost an average of 8.7 letters (1.9 lines), and patients in the 
      PC group an average of 10.0 ETDRS letters (two lines) over 12 months. The mean 
      letters lost at 12 months was not significantly different between the groups, and 
      the MCID was not detected (difference=1.3 letters; P=0.411; 95% confidence 
      interval (-2.3, 5.6)). Patients with occult lesions required a mean of 2.99 
      treatments vs a mean of 2.96 treatments in the PC group (out of a possible 4; 
      P=0.172). CONCLUSION: We were not able to detect a clinically important 
      difference in mean change in visual acuity with PDT treatment between patients 
      with occult and PC lesions.
FAU - Potter, M J
AU  - Potter MJ
AD  - Department of Ophthalmology and Visual Sciences, University of British Columbia, 
      Columbia, Canada. mpotter@ interchange.ubc.ca
FAU - Szabo, S M
AU  - Szabo SM
FAU - Li, W W
AU  - Li WW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20060901
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
RN  - 0 (Photosensitizing Agents)
RN  - 0 (Porphyrins)
RN  - 0X9PA28K43 (Verteporfin)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Choroidal Neovascularization/etiology/physiopathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Macular Degeneration/complications/*drug therapy/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Photochemotherapy/*methods
MH  - Photosensitizing Agents/therapeutic use
MH  - Porphyrins/therapeutic use
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Verteporfin
MH  - *Visual Acuity
EDAT- 2006/09/02 09:00
MHDA- 2008/08/30 09:00
CRDT- 2006/09/02 09:00
PHST- 2006/09/02 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2006/09/02 09:00 [entrez]
AID - 6702547 [pii]
AID - 10.1038/sj.eye.6702547 [doi]
PST - ppublish
SO  - Eye (Lond). 2008 Feb;22(2):194-9. doi: 10.1038/sj.eye.6702547. Epub 2006 Sep 1.