PMID- 16947339
OWN - NLM
STAT- MEDLINE
DCOM- 20070123
LR  - 20161124
IS  - 1053-1807 (Print)
IS  - 1053-1807 (Linking)
VI  - 24
IP  - 4
DP  - 2006 Oct
TI  - Focal nodular hyperplasia: lesion characteristics on state-of-the-art MRI 
      including dynamic gadolinium-enhanced and superparamagnetic iron-oxide-uptake 
      sequences in a prospective study.
PG  - 864-72
AB  - PURPOSE: To image a cohort of patients with pathology-proven focal nodular 
      hyperplasia (FNH) to assess which characteristics of state-of-the-art magnetic 
      resonance imaging (MRI) of the liver are the most useful for improving the 
      detection and characterization of FNH. MATERIALS AND METHODS: In 14 patients, 
      pathology-proven FNH (N=33) were prospectively examined using gadolinium (Gd) and 
      superparamagnetic iron-oxide (SPIO) contrast media. All lesions were evaluated 
      for signal intensity (SI), fatty infiltration, central scar, mode of enhancement 
      with Gd, and uptake of SPIO. The percentage of dynamic contrast enhancement in 
      the arterial, portal, and delayed phases was assessed. The contrast-to-noise 
      ratio (CNR) before and after administration of SPIO contrast was calculated. 
      RESULTS: The SI of the lesions was low to isointense on T1-weighted (T1W) images, 
      and intermediate to isointense on T2W images. Fatty infiltration of the lesions 
      was present in 6%. The percentages of enhancement in the liver and lesion were 
      110%, 115%, and 95%, and 151%, 182%, and 160%, respectively (P<0.0001). All 
      lesions showed uptake of SPIO with improved conspicuity of the central scar and 
      septa. The CNR values precontrast and post-Gd/SPIO were significantly different 
      for T1 in- and opposed-phase and black-blood echo-planar imaging (BBEPI). 
      CONCLUSION: Combining dynamic Gd-enhanced imaging with T1W and T2W sequences 
      after administration of SPIO facilitates comprehensive evaluation of FNH.
CI  - Copyright (c) 2006 Wiley-Liss, Inc.
FAU - Terkivatan, Turkan
AU  - Terkivatan T
AD  - Department of Surgery, Erasmus MC, University Medical Center, Rotterdam, The 
      Netherlands.
FAU - van den Bos, Indra C
AU  - van den Bos IC
FAU - Hussain, Shahid M
AU  - Hussain SM
FAU - Wielopolski, Piotr A
AU  - Wielopolski PA
FAU - de Man, Rob A
AU  - de Man RA
FAU - IJzermans, Jan N M
AU  - IJzermans JN
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Contrast Media)
RN  - 0 (Dextrans)
RN  - 0 (Magnetite Nanoparticles)
RN  - 0 (Oxides)
RN  - E1UOL152H7 (Iron)
RN  - G6N3J05W84 (ferumoxides)
RN  - K2I13DR72L (Gadolinium DTPA)
RN  - XM0M87F357 (Ferrosoferric Oxide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Contrast Media
MH  - Dextrans
MH  - Female
MH  - Ferrosoferric Oxide
MH  - Focal Nodular Hyperplasia/*pathology
MH  - *Gadolinium DTPA
MH  - Humans
MH  - *Iron
MH  - Magnetic Resonance Imaging/*methods
MH  - Magnetite Nanoparticles
MH  - Middle Aged
MH  - *Oxides
MH  - Prospective Studies
MH  - Sensitivity and Specificity
MH  - Statistics, Nonparametric
EDAT- 2006/09/02 09:00
MHDA- 2007/01/24 09:00
CRDT- 2006/09/02 09:00
PHST- 2006/09/02 09:00 [pubmed]
PHST- 2007/01/24 09:00 [medline]
PHST- 2006/09/02 09:00 [entrez]
AID - 10.1002/jmri.20705 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2006 Oct;24(4):864-72. doi: 10.1002/jmri.20705.