PMID- 16949571
OWN - NLM
STAT- MEDLINE
DCOM- 20061212
LR  - 20131121
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 548
IP  - 1-3
DP  - 2006 Oct 24
TI  - Pharmacological therapies against soman-induced seizures in rats 30 min following 
      onset and anticonvulsant impact.
PG  - 83-9
AB  - Systemic administration does not allow a clear differentiation between the 
      anticonvulsant properties of GABAA (gamma-aminobutyric acid) modulators. For this 
      reason, various GABAA modulators have previously been micro-infused into seizure 
      controlling substrates (area tempestas, substantia nigra) in the rat brain as a 
      screening method for potential systemic administration. The purpose of the 
      present study was to examine the anticonvulsant impact of the GABAergic 
      modulators muscimol, ethanol, and propofol (screened by micro-infusions) when 
      each drug was combined with procyclidine and administered systemically. The 
      results showed that all 3 combinations could effectively terminate soman-induced 
      (100 microg/kg s.c.) seizures when administered 30-35 min after onset. 
      Procyclidine and propofol were considered as the most relevant double regimen to 
      replace a previous triple regimen (procyclidine, diazepam, pentobarbital) against 
      soman-induced seizures. Additionally, it was shown that unilateral implantation 
      of hippocampal electrodes resulted in increased resistance to aphagia/adipsia and 
      neuropathology, but not to lethality following soman. Efficient pharmacological 
      treatment of soman-induced seizures at an early stage (< 20 min) is crucial to 
      avoid neuropathology and cognitive deficits.
FAU - Myhrer, Trond
AU  - Myhrer T
AD  - Norwegian Defence Research Establishment, Protection Division, NO-2027 Kjeller, 
      Norway. trond.myhrer@ffi.no
FAU - Enger, Siri
AU  - Enger S
FAU - Aas, Pal
AU  - Aas P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20060713
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Anticonvulsants)
RN  - 0 (Antidotes)
RN  - 0 (GABA Modulators)
RN  - 0 (Muscarinic Antagonists)
RN  - 2763-96-4 (Muscimol)
RN  - 3K9958V90M (Ethanol)
RN  - 96-64-0 (Soman)
RN  - C6QE1Q1TKR (Procyclidine)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Animals
MH  - Anticonvulsants/*pharmacology
MH  - Antidotes/pharmacology
MH  - Ethanol/pharmacology
MH  - GABA Modulators/pharmacology
MH  - Hippocampus/drug effects/physiopathology
MH  - Male
MH  - Muscarinic Antagonists/pharmacology
MH  - Muscimol/pharmacology
MH  - Parietal Lobe/drug effects/physiopathology
MH  - Procyclidine/*pharmacology
MH  - Propofol/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Seizures/chemically induced/*drug therapy/physiopathology
MH  - Soman/*toxicity
EDAT- 2006/09/05 09:00
MHDA- 2006/12/13 09:00
CRDT- 2006/09/05 09:00
PHST- 2006/03/03 00:00 [received]
PHST- 2006/06/19 00:00 [revised]
PHST- 2006/07/04 00:00 [accepted]
PHST- 2006/09/05 09:00 [pubmed]
PHST- 2006/12/13 09:00 [medline]
PHST- 2006/09/05 09:00 [entrez]
AID - S0014-2999(06)00701-1 [pii]
AID - 10.1016/j.ejphar.2006.07.001 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2006 Oct 24;548(1-3):83-9. doi: 10.1016/j.ejphar.2006.07.001. 
      Epub 2006 Jul 13.