PMID- 16950294
OWN - NLM
STAT- MEDLINE
DCOM- 20061017
LR  - 20061115
IS  - 0091-6749 (Print)
IS  - 0091-6749 (Linking)
VI  - 118
IP  - 3
DP  - 2006 Sep
TI  - Hyperresponsive TH2 cells with enhanced nuclear factor-kappa B activation induce 
      atopic dermatitis-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya mice.
PG  - 725-33
AB  - BACKGROUND: Nishiki-nezumi Cinnamon/Nagoya (NC/Nga) mice raised in 
      nonair-controlled conventional circumstances spontaneously develop atopic 
      dermatitis-like skin lesions; however, the underlying mechanisms remain unclear. 
      OBJECTIVE: We wanted to identify the critical intracellular signaling molecules 
      in T cells that induce atopic dermatitis-like skin legions in NC/Nga mice. 
      METHODS: We examined the levels of signal transduction and cytokine production in 
      T cells, particularly those in atopic dermatitis-like lesions induced by the 
      topical injection of mite antigens in NC/Nga mice under specific pathogen-free 
      conditions. RESULTS: In NC/Nga mice maintained under specific pathogen-free 
      conditions, the capability of T(H)1/T(H)2 and T cytotoxic 1/T cytotoxic 2 
      (Tc1/Tc2) cell differentiation increased significantly. T-cell antigen 
      receptor-mediated activation of the extracellular signal-regulated 
      kinase/mitogen-activated protein kinase cascade and nuclear factor-kappaB 
      (NF-kappaB) signaling were enhanced in NC/Nga T cells. The expression of T(H)2 
      cytokines (IL-4, IL-13, and IL-5) and that of GATA-binding protein 3 (GATA3), 
      avian musculoaponeurotic fibrosarcoma (c-Maf), NF-kappaB, and activator protein 1 
      (AP1) selectively increased in draining lymph node T cells of NC/Nga mice. 
      Moreover, the cell transfer of inhibitory NF-kappaB mutant-infected T(H)2 cells 
      reduced ear thickness in the mite antigen-induced skin lesion of NC/Nga mice. 
      CONCLUSION: Hyperresponsive T(H)2 cells with an enhanced activity of NF-kappaB 
      and AP1 play a crucial role in the pathogenesis of atopic dermatitis-like skin 
      lesions in NC/Nga mice. CLINICAL IMPLICATIONS: These results indicate potential 
      therapeutic usefulness of developing selective inhibitors for NF-kappaB in the 
      treatment of human atopic dermatitis.
FAU - Tenda, Yoshiyuki
AU  - Tenda Y
AD  - Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, 
      Japan.
FAU - Yamashita, Masakatsu
AU  - Yamashita M
FAU - Kimura, Motoko Y
AU  - Kimura MY
FAU - Hasegawa, Akihiro
AU  - Hasegawa A
FAU - Shimizu, Chiori
AU  - Shimizu C
FAU - Kitajima, Masayuki
AU  - Kitajima M
FAU - Onodera, Atsushi
AU  - Onodera A
FAU - Suzuki, Akane
AU  - Suzuki A
FAU - Seki, Nobuo
AU  - Seki N
FAU - Nakayama, Toshinori
AU  - Nakayama T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060728
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
RN  - 0 (Cytokines)
RN  - 0 (NF-kappa B)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/immunology
MH  - Cytokines/biosynthesis
MH  - Dermatitis, Atopic/*immunology/metabolism/*pathology
MH  - Lymph Nodes/immunology/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred Strains
MH  - Mites/immunology
MH  - NF-kappa B/*physiology
MH  - Species Specificity
MH  - Th1 Cells/cytology/immunology/metabolism/transplantation
MH  - Th2 Cells/*immunology/*metabolism/transplantation
EDAT- 2006/09/05 09:00
MHDA- 2006/10/18 09:00
CRDT- 2006/09/05 09:00
PHST- 2005/12/26 00:00 [received]
PHST- 2006/05/16 00:00 [revised]
PHST- 2006/05/23 00:00 [accepted]
PHST- 2006/09/05 09:00 [pubmed]
PHST- 2006/10/18 09:00 [medline]
PHST- 2006/09/05 09:00 [entrez]
AID - S0091-6749(06)01301-7 [pii]
AID - 10.1016/j.jaci.2006.05.024 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 2006 Sep;118(3):725-33. doi: 10.1016/j.jaci.2006.05.024. 
      Epub 2006 Jul 28.