PMID- 16950666
OWN - NLM
STAT- MEDLINE
DCOM- 20070116
LR  - 20220317
IS  - 1570-0232 (Print)
IS  - 1570-0232 (Linking)
VI  - 844
IP  - 2
DP  - 2006 Dec 5
TI  - Review of methodology for the determination of macrocyclic lactone residues in 
      biological matrices.
PG  - 175-203
AB  - The macrocyclic lactones (MLs) are probably the anti-parasitic agents most widely 
      used in the treatment of food producing animals, poultry, aquaculture and crops. 
      Ivermectin was the first macrocyclic lactone product to be licensed for use about 
      20 years ago. A number of alternative products such abamectin, doramectin, 
      emamectin, eprinomectin, moxidectin, milbemycin and selamectin, have been 
      marketed since. Because of the increase in the number of ML drugs, there has been 
      a steady increase in the number of published analytical methods for determination 
      of their residues. In this paper, the structure and properties of the different 
      ML drugs available on the market are described. The occurrence and persistence of 
      ML residues in food is discussed in relation to marker residues and current 
      maximum residue limits (MRLs) as defined in the European Union (EU). 
      Methodologies for determination of ML residues in biological matrices are 
      described in terms of extraction and clean-up methods used for different 
      matrices. Detection systems for determination of ML residues are discussed with a 
      particular emphasis placed on new developments in screening technologies and 
      liquid chromatography with fluorescence or mass spectrometry.
FAU - Danaher, Martin
AU  - Danaher M
AD  - Teagasc, Ashtown Food Research Centre, Ashtown, Dublin 15, Ireland. 
      martin.danaher@teagasc.ie <martin.danaher@teagasc.ie>
FAU - Howells, Laurence C
AU  - Howells LC
FAU - Crooks, Steven R H
AU  - Crooks SR
FAU - Cerkvenik-Flajs, Vesna
AU  - Cerkvenik-Flajs V
FAU - O'Keeffe, Michael
AU  - O'Keeffe M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060901
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Macrolides)
RN  - 70288-86-7 (Ivermectin)
RN  - 73989-17-0 (avermectin)
RN  - NGU5H31YO9 (moxidectin)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Chromatography, High Pressure Liquid/methods
MH  - Chromatography, Liquid/methods
MH  - Ivermectin/analogs & derivatives/analysis/chemistry/pharmacokinetics
MH  - Macrolides/*analysis/chemistry/*pharmacokinetics
MH  - Mass Spectrometry/methods
MH  - Molecular Structure
MH  - Spectrometry, Fluorescence/methods
RF  - 177
EDAT- 2006/09/05 09:00
MHDA- 2007/01/17 09:00
CRDT- 2006/09/05 09:00
PHST- 2006/04/22 00:00 [received]
PHST- 2006/07/18 00:00 [revised]
PHST- 2006/07/21 00:00 [accepted]
PHST- 2006/09/05 09:00 [pubmed]
PHST- 2007/01/17 09:00 [medline]
PHST- 2006/09/05 09:00 [entrez]
AID - S1570-0232(06)00631-3 [pii]
AID - 10.1016/j.jchromb.2006.07.035 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Dec 5;844(2):175-203. doi: 
      10.1016/j.jchromb.2006.07.035. Epub 2006 Sep 1.