PMID- 16951285
OWN - NLM
STAT- MEDLINE
DCOM- 20061221
LR  - 20161124
IS  - 0091-4916 (Print)
IS  - 0091-4916 (Linking)
VI  - 34
IP  - 3
DP  - 2006 Sep
TI  - Improved detection and localization of lower gastrointestinal tract hemorrhage by 
      subtraction scintigraphy: phantom analysis.
PG  - 160-8
AB  - Acute lower gastrointestinal tract hemorrhage (LGIH) has significant morbidity 
      and mortality outcomes. Although several causes of LGIH can be life threatening, 
      most can be effectively treated; therefore, early detection and accurate 
      localization of bleeding sites are critical for successful patient management. 
      METHODS: This study was a phantom experimental study with a repeated-measures 
      design. The minimum detectable bleeding rate, the minimum detectable bleed 
      volume, the sensitivity for detection, and the time required for detection were 
      determined and compared for conventional scintigraphy (CS) and 3 experimental 
      techniques: reference subtraction scintigraphy (RSS), sequential subtraction 
      scintigraphy (SSS), and alternate sequential subtraction scintigraphy (ASSS). 
      RESULTS: The minimum detectable bleeding rates within the first hour were 0.05 
      mL.min-1 for CS and RSS, 0.1 mL.min-1 for ASSS, and 0.5 mL.min-1 for SSS. This 
      study demonstrated minimum detectable bleed volumes of 2.2 mL for CS, 2.3 mL for 
      RSS, 5 mL for ASSS, and 5 mL for SSS stratified to a "definitely present" 
      certainty. No statistically significant difference was noted in the mean time to 
      detection between CS and the subtraction techniques. 
      Receiver-operating-characteristic analysis indicated that combining CS and RSS 
      improved test performance and increased overall sensitivity to 75% from 68.3% for 
      CS and 71.7% for RSS. CONCLUSION: Supplementing conventional datasets with RSS 
      and ASSS may provide a useful tool that combines the advantages offered for 
      lesion detectability by a high-contrast 99mTc-sulfur colloid study with the 
      window of opportunity offered by 99mTc-labeled red blood cell scanning.
FAU - Currie, Geoffrey M
AU  - Currie GM
AD  - School of Clinical Sciences, Charles Sturt University, Wagga Wagga, New South 
      Wales, Australia. gcurrie@csu.edu.au
FAU - Towers, Philip A
AU  - Towers PA
FAU - Wheat, Janelle M
AU  - Wheat JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nucl Med Technol
JT  - Journal of nuclear medicine technology
JID - 0430303
RN  - 0 (Radiopharmaceuticals)
RN  - 7440-26-8 (Technetium)
SB  - IM
MH  - Erythrocytes/*diagnostic imaging
MH  - Gastrointestinal Hemorrhage/*diagnostic imaging
MH  - Image Enhancement/*methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Phantoms, Imaging
MH  - Radionuclide Imaging/instrumentation/*methods
MH  - Radiopharmaceuticals
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - *Subtraction Technique
MH  - *Technetium
EDAT- 2006/09/05 09:00
MHDA- 2006/12/22 09:00
CRDT- 2006/09/05 09:00
PHST- 2006/09/05 09:00 [pubmed]
PHST- 2006/12/22 09:00 [medline]
PHST- 2006/09/05 09:00 [entrez]
AID - 34/3/160 [pii]
PST - ppublish
SO  - J Nucl Med Technol. 2006 Sep;34(3):160-8.