PMID- 16951342
OWN - NLM
STAT- MEDLINE
DCOM- 20061024
LR  - 20220321
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 177
IP  - 6
DP  - 2006 Sep 15
TI  - Immature dendritic cells suppress collagen-induced arthritis by in vivo expansion 
      of CD49b+ regulatory T cells.
PG  - 3806-13
AB  - Dendritic cells (DCs) are specialized APCs with an important role in the 
      initiation and regulation of immune responses. Immature DCs (iDCs) reportedly 
      mediate tolerance in the absence of maturation/inflammatory stimuli, presumably 
      by the induction of regulatory T cells. In this study, we show for the first time 
      that repetitive iDC injections trigger the expansion of a novel regulatory 
      population with high immunomodulatory properties, able to protect mice from 
      collagen-induced arthritis. These regulatory T cells are characterized by the 
      expression of the CD49b molecule and correspond to a CD4+ 
      alpha-galactosylceramide/CD1d-nonrestricted T cell population producing IL-10. 
      Adoptive transfer of < 10(5) TCRbeta+ CD49b+ cells isolated from the liver of 
      iDCs-vaccinated mice, conferred a complete protection against arthritis. This 
      protection was associated with an attenuation of the B and T cell response 
      associated with a local secretion of IL-10. Thus, together these data demonstrate 
      that iDCs can expand and activate a novel regulatory population of CD49b+ T 
      cells, with high immunosuppressive potential able to mediate protection against a 
      systemic autoimmune disease.
FAU - Charbonnier, Louis-Marie
AU  - Charbonnier LM
AD  - Institut National de la Sante et de la Recherche Medicale Unite 475, Montpellier, 
      France.
FAU - van Duivenvoorde, Leonie M
AU  - van Duivenvoorde LM
FAU - Apparailly, Florence
AU  - Apparailly F
FAU - Cantos, Celine
AU  - Cantos C
FAU - Han, Wanda G H
AU  - Han WG
FAU - Noel, Daniele
AU  - Noel D
FAU - Duperray, Christophe
AU  - Duperray C
FAU - Huizinga, Tom W J
AU  - Huizinga TW
FAU - Toes, Rene E M
AU  - Toes RE
FAU - Jorgensen, Christian
AU  - Jorgensen C
FAU - Louis-Plence, Pascale
AU  - Louis-Plence P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Integrin alpha2)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adoptive Transfer
MH  - Animals
MH  - Arthritis, Experimental/*immunology/pathology/*prevention & control
MH  - B-Lymphocyte Subsets/immunology/metabolism
MH  - Cell Differentiation/immunology
MH  - *Cell Proliferation
MH  - Cells, Cultured
MH  - Dendritic Cells/*cytology/*immunology/transplantation
MH  - Injections, Intraperitoneal
MH  - Integrin alpha2/*biosynthesis
MH  - Interleukin-10/biosynthesis/metabolism
MH  - Lymph Nodes/cytology/immunology/metabolism
MH  - Lymphocyte Activation/immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - T-Lymphocytes, Regulatory/*immunology/metabolism/*pathology
EDAT- 2006/09/05 09:00
MHDA- 2006/10/25 09:00
CRDT- 2006/09/05 09:00
PHST- 2006/09/05 09:00 [pubmed]
PHST- 2006/10/25 09:00 [medline]
PHST- 2006/09/05 09:00 [entrez]
AID - 177/6/3806 [pii]
AID - 10.4049/jimmunol.177.6.3806 [doi]
PST - ppublish
SO  - J Immunol. 2006 Sep 15;177(6):3806-13. doi: 10.4049/jimmunol.177.6.3806.