PMID- 16951494
OWN - NLM
STAT- MEDLINE
DCOM- 20060921
LR  - 20181113
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2006
IP  - 3
DP  - 2006
TI  - Role of interleukin-18 in modulation of oral carcinoma cell proliferation.
PG  - 67120
LID - 67120
AB  - Interleukin-18 (IL-18), a proinflammatory cytokine, is produced by oral epithelia 
      and carcinoma cells and implicated in tumor regression. Since its direct 
      biological effect on oral cancer cells is not well defined, in this study, we 
      employed a KB cell line to test IL-18 activity. Recombinant human IL-18 
      significantly inhibited KB cell proliferation in a dose-dependent fashion (P < 
      .05) without increasing cytotoxicity. Analysis of its mode of action showed that 
      IL-18 induced cell cycle arrest in the S phase; however, it did not trigger 
      apoptotic cell death. Findings in this study indicate that the suppression of KB 
      cell proliferation was attributed to the modulation of cell cycle progression, 
      providing a new role of this cytokine in antitumor mechanisms.
FAU - Nilkaeo, Athip
AU  - Nilkaeo A
AD  - Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat 
      Yai, Songkla 90112, Thailand.
FAU - Bhuvanath, Suthinee
AU  - Bhuvanath S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (IL18R1 protein, human)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-18 Receptor alpha Subunit)
RN  - 0 (Receptors, Interleukin)
RN  - 0 (Receptors, Interleukin-18)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
EIN - Mediators Inflamm. 2018 Oct 17;2018:9731639. PMID: 30420792
MH  - Apoptosis
MH  - Cell Cycle
MH  - Cell Proliferation
MH  - Humans
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-18/*physiology
MH  - Interleukin-18 Receptor alpha Subunit
MH  - KB Cells
MH  - Mouth Neoplasms/*pathology
MH  - Receptors, Interleukin/analysis
MH  - Receptors, Interleukin-18
PMC - PMC1592604
EDAT- 2006/09/05 09:00
MHDA- 2006/09/22 09:00
PMCR- 2006/01/01
CRDT- 2006/09/05 09:00
PHST- 2006/09/05 09:00 [pubmed]
PHST- 2006/09/22 09:00 [medline]
PHST- 2006/09/05 09:00 [entrez]
PHST- 2006/01/01 00:00 [pmc-release]
AID - S0962935106671202 [pii]
AID - 10.1155/MI/2006/67120 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2006;2006(3):67120. doi: 10.1155/MI/2006/67120.