PMID- 16951768
OWN - NLM
STAT- MEDLINE
DCOM- 20070518
LR  - 20151119
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 27
IP  - 9
DP  - 2006 Sep
TI  - Does thymidine phosphorylase correlate with angiogenesis in intraductal carcinoma 
      of the breast?
PG  - 1329-33
AB  - OBJECTIVE: To determine the association between thymidine phosphorylase (TP) and 
      angiogenesis, and other conventional prognostic markers. We also evaluated 
      interobserver and intraobserver reliability for TP expression in ductal 
      carcinoma, to achieve a more consistent results. METHODS: Our study included all 
      cases diagnosed in Adnan Menderes University Medical Faculty Hospital, Aydin, 
      Turkey as invasive ductal carcinoma or ductal carcinoma in situ (DCIS) with 
      proven component of (>30%), between January 2003 and February 2005. The total 
      number of the cases was 27 and their median age was 50 years. All sections were 
      stained using monoclonal antibody-TP and examined at x40 magnification. Either 
      nuclear or cytoplasmic staining was accepted as positive. The histoscore 
      (H-score) was calculated for each specimen. The tumor stromal vascularity was 
      assessed by monoclonal anti-CD34; and areas of intense vascularization were 
      determined. Conventional immunohistochemical markers such as c-erb B2, Ki-67, 
      estrogen and progesterone receptors and p53 were also applied to all slides. 
      Three pathologists blindly examined each slide under 10 high-power fields (10 
      HPF) for 2 times in a 2 months period. RESULTS: There was no significant 
      association between stromal vascularity and TP staining of cancer cells (p=0.1) 
      and no correlation was determined between H-scores for TP staining in ductal 
      carcinoma and DCIS components (p=0.5). CONCLUSION: There was no significant 
      correlation noted between stromal and periductal vascularity with the anti-CD34 
      antibody was used. No significant correlation was identified between the TP 
      H-score and stromal or periductal vascularity.
FAU - Erkus, Muhan
AU  - Erkus M
AD  - Department of Pathology, Faculty of Medicine, Adnan Menderes University, Aydin 
      09100, Turkey. muhanerkus@hotmail.com
FAU - Meteoglu, Ibrahim
AU  - Meteoglu I
FAU - Culhaci, Nil
AU  - Culhaci N
FAU - Meydan, Nezih
AU  - Meydan N
FAU - Erdogdu, Ibrahim
AU  - Erdogdu I
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
RN  - 0 (Antigens, CD34)
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.4.2.4 (Thymidine Phosphorylase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antigens, CD34/analysis/metabolism
MH  - Biomarkers, Tumor/analysis/metabolism
MH  - Breast Neoplasms/blood supply/*metabolism/pathology
MH  - Carcinoma, Ductal, Breast/blood supply/*metabolism/pathology
MH  - Carcinoma, Intraductal, Noninfiltrating/blood supply/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Middle Aged
MH  - Neovascularization, Pathologic/*metabolism
MH  - Observer Variation
MH  - Prognosis
MH  - Thymidine Phosphorylase/analysis/*metabolism
MH  - Turkey
EDAT- 2006/09/05 09:00
MHDA- 2007/05/19 09:00
CRDT- 2006/09/05 09:00
PHST- 2006/09/05 09:00 [pubmed]
PHST- 2007/05/19 09:00 [medline]
PHST- 2006/09/05 09:00 [entrez]
AID - 20060285' [pii]
PST - ppublish
SO  - Saudi Med J. 2006 Sep;27(9):1329-33.