PMID- 16952403
OWN - NLM
STAT- MEDLINE
DCOM- 20061109
LR  - 20141120
IS  - 0165-2478 (Print)
IS  - 0165-2478 (Linking)
VI  - 107
IP  - 1
DP  - 2006 Sep 15
TI  - Comparative study of the anti-inflammatory effect of two intravenous 
      immunoglobulin preparations manufactured by different processes.
PG  - 58-62
AB  - Intravenous immunoglobulin (IVIG) is increasingly used in the treatment of 
      diverse immune-mediated disorders. Since several preparations of IVIG are 
      available for therapy, it is possible that different manufacturing processes 
      might influence clinical efficacy of IVIG. An insight into the mechanisms of 
      action of such different IVIG preparations is therefore necessary that will 
      provide further guidelines for the utility of IVIG preparations in autoimmune and 
      inflammatory diseases. Since endothelial cells (EC) influence the inflammatory 
      process via production of cytokines, chemokines and expression of adhesive 
      molecules, we analyzed the anti-inflammatory effect on EC of two IVIG 
      preparations: caprylated IVIG (IVIG-C) versus solvent/detergent-treated IVIG 
      (IVIG-SD) preparation. We found that both IVIG preparations inhibit in an 
      equivalent manner, the expression of different pro-inflammatory factors such as 
      IL-6, IL-8, GM-CSF, IL-1beta and TNF-alpha and the adhesion molecules ICAM-1 and 
      VCAM-1. Our results thus suggest that the caprylate while inactivating the virus 
      and enhancing the yield of IgG during IVIG formulation, does not modulate the 
      immunomodulatory properties of IVIG at EC level and that the two preparations 
      show similar anti-inflammatory effects.
FAU - Elluru, Sriramulu
AU  - Elluru S
AD  - INSERM U681, Universite Pierre et Marie Curie, UPMC, Paris 6, Institut des 
      Cordeliers, 15 Rue de l'Ecole de Medecine, 75006 Paris, France.
FAU - Duong Van Huyen, Jean-Paul
AU  - Duong Van Huyen JP
FAU - Prost, Fabienne
AU  - Prost F
FAU - Delignat, Sandrine
AU  - Delignat S
FAU - Bayry, Jagadeesh
AU  - Bayry J
FAU - Ephrem, Amal
AU  - Ephrem A
FAU - Siberil, Sophie
AU  - Siberil S
FAU - Misra, Namita
AU  - Misra N
FAU - Lacroix-Desmzes, Sebastien
AU  - Lacroix-Desmzes S
FAU - Kazatchkine, Michel D
AU  - Kazatchkine MD
FAU - Kaveri, Srini V
AU  - Kaveri SV
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060822
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 0 (Caprylates)
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunologic Factors)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
EIN - Immunol Lett. 2006 Nov 15;107(2):182
MH  - Caprylates
MH  - Cell Culture Techniques/methods
MH  - Cytokines/metabolism
MH  - Endothelial Cells/immunology/metabolism
MH  - Humans
MH  - Immunoglobulins, Intravenous/*chemistry/*pharmacology
MH  - Immunologic Factors/*pharmacology
MH  - Inflammation/immunology/prevention & control
MH  - Intercellular Adhesion Molecule-1/metabolism
MH  - Umbilical Veins/immunology
MH  - Vascular Cell Adhesion Molecule-1/metabolism
EDAT- 2006/09/06 09:00
MHDA- 2006/11/11 09:00
CRDT- 2006/09/06 09:00
PHST- 2006/06/28 00:00 [received]
PHST- 2006/07/27 00:00 [revised]
PHST- 2006/07/28 00:00 [accepted]
PHST- 2006/09/06 09:00 [pubmed]
PHST- 2006/11/11 09:00 [medline]
PHST- 2006/09/06 09:00 [entrez]
AID - S0165-2478(06)00202-1 [pii]
AID - 10.1016/j.imlet.2006.07.009 [doi]
PST - ppublish
SO  - Immunol Lett. 2006 Sep 15;107(1):58-62. doi: 10.1016/j.imlet.2006.07.009. Epub 
      2006 Aug 22.