PMID- 16954657
OWN - NLM
STAT- MEDLINE
DCOM- 20060918
LR  - 20061115
IS  - 1424-859X (Electronic)
IS  - 1424-8581 (Linking)
VI  - 114
IP  - 3-4
DP  - 2006
TI  - COmbined Binary RAtio fluorescence in situ hybridiziation (COBRA-FISH): 
      development and applications.
PG  - 222-6
AB  - The ability to probe for the location of DNA sequences in morphologically 
      preserved chromosomes and nuclei by fluorescence in situ hybridization (FISH) 
      provided for cytogenetics a quantum leap forward in resolution and ease of 
      detection of chromosomal aberrations. COBRA-FISH, an acronym for COmbined Binary 
      RAtio-FISH is a multicolor FISH methodology, which enables recognition of all 
      human chromosome arms on the basis of color, thus greatly facilitating 
      cytogenetic analysis. It also permits gene and viral integration site mapping in 
      the context of chromosome arm painting. Here we review the principle, practice 
      and applications of COBRA-FISH.
CI  - Copyright 2006 S. Karger AG, Basel.
FAU - Raap, A K
AU  - Raap AK
AD  - Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, 
      The Netherlands. a.k.raap@lumc.nl
FAU - Tanke, H J
AU  - Tanke HJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Switzerland
TA  - Cytogenet Genome Res
JT  - Cytogenetic and genome research
JID - 101142708
RN  - 0 (Fluorescent Dyes)
SB  - IM
MH  - Fluorescent Dyes
MH  - Humans
MH  - In Situ Hybridization/*methods/*trends
MH  - In Situ Hybridization, Fluorescence/*methods/*trends
MH  - Models, Genetic
RF  - 28
EDAT- 2006/09/07 09:00
MHDA- 2006/09/19 09:00
CRDT- 2006/09/07 09:00
PHST- 2005/11/01 00:00 [received]
PHST- 2005/12/20 00:00 [accepted]
PHST- 2006/09/07 09:00 [pubmed]
PHST- 2006/09/19 09:00 [medline]
PHST- 2006/09/07 09:00 [entrez]
AID - 94204 [pii]
AID - 10.1159/000094204 [doi]
PST - ppublish
SO  - Cytogenet Genome Res. 2006;114(3-4):222-6. doi: 10.1159/000094204.