PMID- 16954661 OWN - NLM STAT- MEDLINE DCOM- 20060918 LR - 20181201 IS - 1424-859X (Electronic) IS - 1424-8581 (Linking) VI - 114 IP - 3-4 DP - 2006 TI - Multicolor chromosome bar codes. PG - 245-9 AB - Chromosome bar codes are multicolor banding patterns produced by fluorescence in situ hybridization (FISH) with differentially labeled and pooled sub-regional DNA probes. These molecular cytogenetic tools facilitate chromosome identification and the delineation of both inter- and intra-chromosomal rearrangements. We present an overview of the various conceptual approaches which can be largely divided into two classes: Simple bar codes designed for chromosome identification and complex bar codes for high resolution aberration screening of entire karyotypes. We address the issue of color redundancy and how to overcome this limitation by complementation of bar codes with whole chromosome painting probes. CI - Copyright 2006 S. Karger AG, Basel. FAU - Muller, S AU - Muller S AD - Institute for Anthropology and Human Genetics, Department of Biology II, Ludwig-Maximilians-University, Munich, Germany. s.mueller@lrz.uni-muenchen.de FAU - Wienberg, J AU - Wienberg J LA - eng PT - Journal Article PT - Review PL - Switzerland TA - Cytogenet Genome Res JT - Cytogenetic and genome research JID - 101142708 RN - 0 (DNA Probes) SB - IM MH - Chromosome Aberrations MH - Chromosome Banding MH - Chromosome Mapping/*methods MH - Chromosome Painting/*methods MH - DNA Probes MH - Electronic Data Processing/*methods MH - Gene Rearrangement MH - Humans MH - In Situ Hybridization, Fluorescence/methods MH - Karyotyping/methods MH - Translocation, Genetic RF - 31 EDAT- 2006/09/07 09:00 MHDA- 2006/09/19 09:00 CRDT- 2006/09/07 09:00 PHST- 2005/11/30 00:00 [received] PHST- 2006/04/03 00:00 [accepted] PHST- 2006/09/07 09:00 [pubmed] PHST- 2006/09/19 09:00 [medline] PHST- 2006/09/07 09:00 [entrez] AID - 94208 [pii] AID - 10.1159/000094208 [doi] PST - ppublish SO - Cytogenet Genome Res. 2006;114(3-4):245-9. doi: 10.1159/000094208.