PMID- 16954806
OWN - NLM
STAT- MEDLINE
DCOM- 20070111
LR  - 20180913
IS  - 1078-0998 (Print)
IS  - 1078-0998 (Linking)
VI  - 12
IP  - 9
DP  - 2006 Sep
TI  - The role of vascular endothelial growth factor (VEGF) in inflammatory bowel 
      disease.
PG  - 870-8
AB  - BACKGROUND: Vascular endothelial growth factor (VEGF) is a candidate 
      susceptibility gene to inflammatory bowel disease (IBD), both from a functional 
      as well as genetic perspective. Moreover, serum VEGF (sVEGF) levels are increased 
      in IBD and correlate with disease activity. Both VEGF expression and sVEGF levels 
      may be influenced by VEGF gene polymorphisms. AIMS: To study VEGF polymorphisms 
      in IBD susceptibility and their impact on sVEGF levels. METHODS: Four functional 
      VEGF polymorphisms (-C2578A, -G1154A, -G634C, and C936T) were genotyped in two 
      independent cohorts (cohort 1: 372 IBD trios; cohort 2: 452 unrelated IBD 
      patients, 271 healthy controls [HC]; and 93 patients with non-IBD 
      gastrointestinal inflammation [non-IBD GI]), using polymerase chain reaction with 
      restriction fragment length polymorphism and TaqMan minor groove binding. 
      Phenotypical data on all patients as well as sVEGF levels were correlated with 
      the genetic data. RESULTS: Both the VEGF genotype and haplotype frequencies did 
      not differ between IBD patients and controls, and no distortion of transmission 
      was observed. sVEGF levels were increased in IBD but also in non-IBD GI patients, 
      compared with HC, and were only influenced by VEGF polymorphisms in patients with 
      Crohn's disease (-G1154A genotype and -2578/-1154/-634 AAG promoter haplotype). 
      CONCLUSIONS: The VEGF polymorphisms studied are not implicated in susceptibility 
      to IBD and do not predict sVEGF levels. Although increased sVEGF and angiogenesis 
      are important features of IBD, they do not appear genetically determined.
FAU - Ferrante, Marc
AU  - Ferrante M
AD  - Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, 
      Belgium.
FAU - Pierik, Marie
AU  - Pierik M
FAU - Henckaerts, Liesbet
AU  - Henckaerts L
FAU - Joossens, Marie
AU  - Joossens M
FAU - Claes, Karolien
AU  - Claes K
FAU - Van Schuerbeek, Nele
AU  - Van Schuerbeek N
FAU - Vlietinck, Robert
AU  - Vlietinck R
FAU - Rutgeerts, Paul
AU  - Rutgeerts P
FAU - Van Assche, Gert
AU  - Van Assche G
FAU - Vermeire, Severine
AU  - Vermeire S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Inflamm Bowel Dis
JT  - Inflammatory bowel diseases
JID - 9508162
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cohort Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Haplotypes/genetics
MH  - Humans
MH  - Inflammatory Bowel Diseases/blood/*genetics
MH  - Linkage Disequilibrium/genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Vascular Endothelial Growth Factor A/blood/*genetics
EDAT- 2006/09/07 09:00
MHDA- 2007/01/12 09:00
CRDT- 2006/09/07 09:00
PHST- 2006/09/07 09:00 [pubmed]
PHST- 2007/01/12 09:00 [medline]
PHST- 2006/09/07 09:00 [entrez]
AID - 00054725-200609000-00006 [pii]
AID - 10.1097/01.mib.0000235095.01608.10 [doi]
PST - ppublish
SO  - Inflamm Bowel Dis. 2006 Sep;12(9):870-8. doi: 10.1097/01.mib.0000235095.01608.10.