PMID- 16955067
OWN - NLM
STAT- MEDLINE
DCOM- 20061016
LR  - 20220409
IS  - 1474-1776 (Print)
IS  - 1474-1784 (Electronic)
IS  - 1474-1776 (Linking)
VI  - 5
IP  - 9
DP  - 2006 Sep
TI  - NO-independent stimulators and activators of soluble guanylate cyclase: discovery 
      and therapeutic potential.
PG  - 755-68
AB  - Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by 
      nitric oxide (NO). Impaired bioavailability and/or responsiveness to endogenous 
      NO has been implicated in the pathogenesis of cardiovascular and other diseases. 
      Current therapies that involve the use of organic nitrates and other NO donors 
      have limitations, including non-specific interactions of NO with various 
      biomolecules, lack of response and the development of tolerance following 
      prolonged administration. Compounds that activate sGC in an NO-independent manner 
      might therefore provide considerable therapeutic advantages. Here we review the 
      discovery, biochemistry, pharmacology and clinical potential of haem-dependent 
      sGC stimulators (including YC-1, BAY 41-2272, BAY 41-8543, CFM-1571 and A-350619) 
      and haem-independent sGC activators (including BAY 58-2667 and HMR-1766).
FAU - Evgenov, Oleg V
AU  - Evgenov OV
AD  - Department of Anesthesia and Critical Care, Massachusetts General Hospital, 
      Harvard Medical School, 55 Fruit Street, CLN 309, Boston, Massachusetts 02114, 
      USA.
FAU - Pacher, Pal
AU  - Pacher P
FAU - Schmidt, Peter M
AU  - Schmidt PM
FAU - Hasko, Gyorgy
AU  - Hasko G
FAU - Schmidt, Harald H H W
AU  - Schmidt HH
FAU - Stasch, Johannes-Peter
AU  - Stasch JP
LA  - eng
GR  - Z01 AA000375-02/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Rev Drug Discov
JT  - Nature reviews. Drug discovery
JID - 101124171
RN  - 0 (Enzyme Activators)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 4.6.1.2 (Guanylate Cyclase)
SB  - IM
MH  - Animals
MH  - Drug Design
MH  - Enzyme Activation/drug effects
MH  - Enzyme Activators/chemistry/*pharmacology/therapeutic use
MH  - Guanylate Cyclase/*metabolism
MH  - Humans
MH  - Molecular Structure
MH  - Nitric Oxide/*metabolism
PMC - PMC2225477
MID - NIHMS38124
EDAT- 2006/09/07 09:00
MHDA- 2006/10/17 09:00
PMCR- 2008/02/03
CRDT- 2006/09/07 09:00
PHST- 2006/09/07 09:00 [pubmed]
PHST- 2006/10/17 09:00 [medline]
PHST- 2006/09/07 09:00 [entrez]
PHST- 2008/02/03 00:00 [pmc-release]
AID - nrd2038 [pii]
AID - 10.1038/nrd2038 [doi]
PST - ppublish
SO  - Nat Rev Drug Discov. 2006 Sep;5(9):755-68. doi: 10.1038/nrd2038.