PMID- 16956691
OWN - NLM
STAT- MEDLINE
DCOM- 20070425
LR  - 20071115
IS  - 0168-8227 (Print)
IS  - 0168-8227 (Linking)
VI  - 76
IP  - 1
DP  - 2007 Apr
TI  - Plasma visfatin levels in patients with newly diagnosed and untreated type 2 
      diabetes mellitus and impaired glucose tolerance.
PG  - 24-9
AB  - Visfatin, a new adipokine, facilitates adipogenesis and has insulin-mimetic 
      properties. We aimed to investigate the plasma visfatin levels in patients with 
      newly diagnosed and untreated type 2 diabetes mellitus (T2DM) and impaired 
      glucose tolerance (IGT), who had no obesity or hypertension. Twenty-two patients 
      with T2DM, 18 subjects with IGT and 40 healthy controls were enrolled. Visfatin 
      levels were measured along with the BMI, blood pressure, lipids, glucose, 
      insulin, adiponectin and hsCRP levels, and HOMA-IR indexes. Age, sex and BMI were 
      similar in all groups. Visfatin levels were higher in the diabetic group than the 
      controls (p=0.01). There was no significant difference in the visfatin levels 
      between the T2DM and IGT groups as well as IGT group and healthy controls. Plasma 
      visfatin concentrations did not differ between men and women. Visfatin levels did 
      not correlate with BMI, blood pressure, plasma adiponectin, insulin, hsCRP, 
      glucose and lipid levels or HOMA-IR indexes in the three groups. These results 
      indicate that hyperglycemia causes an increase in plasma visfatin levels and, as 
      in people with T2DM but not with IGT, this increase gets more prominent as the 
      glucose intolerance worsens.
FAU - Dogru, Teoman
AU  - Dogru T
AD  - Department of Internal Medicine, Gulhane School of Medicine, Etlik, Ankara, 
      Turkey. teomandogru@yahoo.com
FAU - Sonmez, Alper
AU  - Sonmez A
FAU - Tasci, Ilker
AU  - Tasci I
FAU - Bozoglu, Ergun
AU  - Bozoglu E
FAU - Yilmaz, Mahmut Ilker
AU  - Yilmaz MI
FAU - Genc, Halil
AU  - Genc H
FAU - Erdem, Gokhan
AU  - Erdem G
FAU - Gok, Mahmut
AU  - Gok M
FAU - Bingol, Necati
AU  - Bingol N
FAU - Kilic, Selim
AU  - Kilic S
FAU - Ozgurtas, Taner
AU  - Ozgurtas T
FAU - Bingol, Sezin
AU  - Bingol S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060907
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Blood Glucose)
RN  - 0 (Cytokines)
RN  - EC 2.4.2.12 (Nicotinamide Phosphoribosyltransferase)
RN  - EC 2.4.2.12 (nicotinamide phosphoribosyltransferase, human)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Case-Control Studies
MH  - Cytokines/*blood
MH  - Diabetes Mellitus, Type 2/*blood/*diagnosis
MH  - Fasting
MH  - Female
MH  - Glucose Intolerance/*blood
MH  - Glucose Tolerance Test/methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nicotinamide Phosphoribosyltransferase
EDAT- 2006/09/08 09:00
MHDA- 2007/04/26 09:00
CRDT- 2006/09/08 09:00
PHST- 2006/05/02 00:00 [received]
PHST- 2006/07/31 00:00 [accepted]
PHST- 2006/09/08 09:00 [pubmed]
PHST- 2007/04/26 09:00 [medline]
PHST- 2006/09/08 09:00 [entrez]
AID - S0168-8227(06)00349-4 [pii]
AID - 10.1016/j.diabres.2006.07.031 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2007 Apr;76(1):24-9. doi: 10.1016/j.diabres.2006.07.031. 
      Epub 2006 Sep 7.