PMID- 16956953
OWN - NLM
STAT- MEDLINE
DCOM- 20061204
LR  - 20181113
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 80
IP  - 21
DP  - 2006 Nov
TI  - Signal transduction by human herpesvirus 8 viral interleukin-6 (vIL-6) is 
      modulated by the nonsignaling gp80 subunit of the IL-6 receptor complex and is 
      distinct from signaling induced by human IL-6.
PG  - 10874-8
AB  - Human herpesvirus 8 (HHV-8) viral interleukin-6 (vIL-6) mediates signaling 
      through the gp130 signal transducer but unlike human IL-6 (hIL-6) does not 
      require the nonsignaling gp80 alpha subunit of the IL-6 receptor complex. By 
      utilizing a gp80-refractory vIL-6 variant, vIL-6(R189L), we found that signal 
      transduction, as measured by STAT1 and STAT3 activation and gp130 tyrosine 
      phosphorylation in gp80+/gp130+ HEK293T cells, was modulated by gp80. 
      Furthermore, the signaling and BAF-130 cell growth-promoting activities of vIL-6 
      and hIL-6 could be distinguished, and exogenous addition of soluble gp80 enhanced 
      cell growth supported by vIL-6. Our findings demonstrate that gp80 can modulate 
      vIL-6 activity and that vIL-6 and hIL-6 signaling are not directly equivalent.
FAU - Hu, Fang
AU  - Hu F
AD  - SKCCC at Johns Hopkins, 1650 Orleans Street, Room 309, Baltimore, MD 21231, USA.
FAU - Nicholas, John
AU  - Nicholas J
LA  - eng
GR  - R01 CA076445/CA/NCI NIH HHS/United States
GR  - CA76445/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060906
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Interleukin-6)
RN  - 0 (Protein Subunits)
RN  - 0 (Receptors, Interleukin-6)
RN  - 0 (STAT1 Transcription Factor)
RN  - 0 (STAT1 protein, human)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT3 protein, human)
RN  - 0 (Viral Proteins)
RN  - 0 (interleukin-6 receptor alpha)
RN  - 133483-10-0 (Cytokine Receptor gp130)
SB  - IM
MH  - Cell Line
MH  - Cytokine Receptor gp130/physiology
MH  - Genetic Variation
MH  - Herpesvirus 8, Human/genetics/*immunology/physiology
MH  - Humans
MH  - Interleukin-6/genetics/*physiology
MH  - Protein Subunits
MH  - Receptors, Interleukin-6/chemistry/genetics/*physiology
MH  - STAT1 Transcription Factor/metabolism
MH  - STAT3 Transcription Factor/metabolism
MH  - Signal Transduction
MH  - Viral Proteins/genetics/immunology/*physiology
PMC - PMC1641745
EDAT- 2006/09/08 09:00
MHDA- 2006/12/09 09:00
PMCR- 2007/03/01
CRDT- 2006/09/08 09:00
PHST- 2006/09/08 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/09/08 09:00 [entrez]
PHST- 2007/03/01 00:00 [pmc-release]
AID - JVI.00767-06 [pii]
AID - 0767-06 [pii]
AID - 10.1128/JVI.00767-06 [doi]
PST - ppublish
SO  - J Virol. 2006 Nov;80(21):10874-8. doi: 10.1128/JVI.00767-06. Epub 2006 Sep 6.