PMID- 16958132
OWN - NLM
STAT- MEDLINE
DCOM- 20070103
LR  - 20131121
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 84
IP  - 7
DP  - 2006 Nov 15
TI  - Ethyl pyruvate attenuates kainic acid-induced neuronal cell death in the mouse 
      hippocampus.
PG  - 1505-11
AB  - Recent studies have shown that ethyl pyruvate (EP) acts as an anti-inflammatory 
      molecule in several cell lines including RAW264.7 macrophages. However, the 
      potential therapeutic value of EP for the treatment of the pathologic brain has 
      not been investigated fully. In the present study, we examined whether EP has a 
      beneficial effect on KA-induced neuronal cell death. Intracerebroventricular 
      (i.c.v.) injection of 0.94 nmol (0.2 mug) of KA produced typical neuronal cell 
      death in the CA1 and CA3 pyramidal layers of the hippocampus, and the systemic 
      administration of EP significantly attenuated KA-induced neuronal cell death in 
      these regions. Ethyl pyruvate was found to exert a protective effect when it was 
      injected as late as 12 hr after KA-injection. Moreover, this EP-induced 
      neuroprotection was accompanied by reduced levels of reactive gliosis and COX-2, 
      IL-1beta, and TNF-alpha in the hippocampus. In addition, in passive avoidance 
      tests, KA-induced memory impairment was improved markedly by EP. These results 
      suggest that EP has a therapeutic potential for suppressing KA-induced 
      pathogenesis in the brain.
FAU - Cho, Ik-Hyun
AU  - Cho IH
AD  - Ewha Institute of Neuroscience and Department of Neuroscience, Ewha Womans 
      University, Seoul, Republic of Korea.
FAU - Kim, Seung-Woo
AU  - Kim SW
FAU - Kim, Jung-Bin
AU  - Kim JB
FAU - Kim, Tae-Kyung
AU  - Kim TK
FAU - Lee, Kang-Woo
AU  - Lee KW
FAU - Han, Pyung-Lim
AU  - Han PL
FAU - Lee, Ja-Kyeong
AU  - Lee JK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Pyruvates)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 03O98E01OB (ethyl pyruvate)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/drug effects/physiology
MH  - Behavior, Animal/drug effects
MH  - Cell Count/methods
MH  - Cell Death/drug effects
MH  - Cyclooxygenase 2/genetics/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Excitatory Amino Acid Agonists/toxicity
MH  - Hippocampus/*pathology
MH  - Immunohistochemistry/methods
MH  - Interleukin-1beta/genetics/metabolism
MH  - Kainic Acid/toxicity
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neurons/*drug effects
MH  - Neuroprotective Agents/*pharmacology
MH  - Neurotoxicity Syndromes/etiology/pathology/physiopathology/*prevention & control
MH  - Pyruvates/*pharmacology
MH  - RNA, Messenger/biosynthesis
MH  - Reaction Time/drug effects
MH  - Reverse Transcriptase Polymerase Chain Reaction/methods
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
EDAT- 2006/09/08 09:00
MHDA- 2007/01/04 09:00
CRDT- 2006/09/08 09:00
PHST- 2006/09/08 09:00 [pubmed]
PHST- 2007/01/04 09:00 [medline]
PHST- 2006/09/08 09:00 [entrez]
AID - 10.1002/jnr.21052 [doi]
PST - ppublish
SO  - J Neurosci Res. 2006 Nov 15;84(7):1505-11. doi: 10.1002/jnr.21052.