PMID- 16959002
OWN - NLM
STAT- MEDLINE
DCOM- 20061020
LR  - 20191210
IS  - 1075-122X (Print)
IS  - 1075-122X (Linking)
VI  - 12
IP  - 5 Suppl 2
DP  - 2006 Sep-Oct
TI  - Human leukocyte antigen as a predictive factor of developing bilateral breast 
      cancer in Japanese women.
PG  - S201-3
AB  - To investigate the relationship between human leukocyte antigen (HLA) type and 
      bilateral breast cancer, a total of 213 female breast cancer patients were 
      entered into this study. The lymphocyte cytotoxicity test was used for HLA 
      typing. HLA frequency and haplotype antigen frequency were calculated with a 
      microcomputer. A chi-squared test was used for comparing HLA frequency. At the 
      start point of follow-up, 187 patients (87.8%) had unilateral and 26 patients 
      (12.2%) had bilateral breast cancer. After a 10-year follow-up, 183 patients 
      (85.9%) were unilateral and 30 patients (14.1%) were bilateral. Haplotype 
      frequency of A24-Cw7 was significantly higher in bilateral breast cancer patients 
      compared with unilateral breast cancer patients (p < 0.001). After the 10-year 
      follow-up, 4 of 187 patients (2.1%) with unilateral breast cancer developed 
      bilateral breast cancer. Two of 19 patients (10.5%) with haplotype A24-Cw7 
      developed bilateral breast cancer, whereas only 2 of 168 patients (1.2%) without 
      haplotype A24-Cw7 developed bilateral breast cancer (p < 0.01). The true 
      frequency of developing contralateral breast cancer in patients with haplotype 
      A24-Cw7 was 93 per 100,000 per year. The risk of bilateral breast cancer in 
      patients with haplotype A24 and Cw7 is 12 times higher compared with those 
      without the haplotype. HLA typing is useful for selecting patients who are at 
      high risk of contralateral breast cancer.
FAU - Yokoe, Takao
AU  - Yokoe T
AD  - Department of Surgery, Shibukawa General Hospital, Gunma University Graduate 
      School of Medicine, Gunma, Japan. takayok@sougoubyouin.shibukawa.gunma.jp
FAU - Horiguchi, Jun
AU  - Horiguchi J
FAU - Koibuchi, Yukio
AU  - Koibuchi Y
FAU - Takei, Hiroyuki
AU  - Takei H
FAU - Yoshida, Takashi
AU  - Yoshida T
FAU - Iijima, Kotaro
AU  - Iijima K
FAU - Yoshida, Miho
AU  - Yoshida M
FAU - Iino, Yuichi
AU  - Iino Y
FAU - Morishita, Yasuo
AU  - Morishita Y
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Breast J
JT  - The breast journal
JID - 9505539
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Biomarkers, Tumor/*metabolism
MH  - Breast Neoplasms/epidemiology/*metabolism/mortality/pathology
MH  - Female
MH  - HLA Antigens/*metabolism
MH  - Humans
MH  - Incidence
MH  - Japan/epidemiology
MH  - Medical Records
MH  - Neoplasm Metastasis/diagnosis
MH  - Predictive Value of Tests
MH  - Retrospective Studies
EDAT- 2006/09/09 09:00
MHDA- 2006/10/21 09:00
CRDT- 2006/09/09 09:00
PHST- 2006/09/09 09:00 [pubmed]
PHST- 2006/10/21 09:00 [medline]
PHST- 2006/09/09 09:00 [entrez]
AID - TBJ335 [pii]
AID - 10.1111/j.1075-122X.2006.00335.x [doi]
PST - ppublish
SO  - Breast J. 2006 Sep-Oct;12(5 Suppl 2):S201-3. doi: 
      10.1111/j.1075-122X.2006.00335.x.