PMID- 16960025 OWN - NLM STAT- MEDLINE DCOM- 20061012 LR - 20220331 IS - 1079-5006 (Print) IS - 1758-535X (Electronic) IS - 1079-5006 (Linking) VI - 61 IP - 9 DP - 2006 Sep TI - One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue. PG - 943-50 AB - BACKGROUND: Caloric restriction (CR) increases maximal life span in short-lived organisms, and its effects are being explored in nonhuman primates. The objectives of this study were to determine the feasibility of prolonged CR in nonobese adults and to compare the effects of CR- and exercise-induced weight loss on body composition and abdominal adiposity. METHODS: A randomized, controlled trial was conducted with 48 healthy, nonobese women and men, aged 57 +/- 1 (mean +/- standard error [SE]) years, with body mass index 27.3 +/- 0.3 kg/m2. Participants were randomly assigned to a 20% calorically-restricted diet (CR, n = 19), exercise designed to produce a similar energy deficit (EX, n = 19), or a healthy lifestyle control group (HL, n = 10) for 1 year. Assessments included weight, body composition by dual-energy x-ray absorptiometry, abdominal adipose tissue by magnetic resonance imaging, and energy intake by doubly labeled water. RESULTS: The average level of CR achieved by the CR group was 11.5 +/- 2.1%, and the EX group completed 59 +/- 6.7% of their prescribed exercise. Weight changes were greater (p