PMID- 16960807
OWN - NLM
STAT- MEDLINE
DCOM- 20061031
LR  - 20200824
IS  - 0002-9297 (Print)
IS  - 1537-6605 (Electronic)
IS  - 0002-9297 (Linking)
VI  - 79
IP  - 4
DP  - 2006 Oct
TI  - HLA-B maternal-fetal genotype matching increases risk of schizophrenia.
PG  - 710-5
AB  - Schizophrenia and human leukocyte antigen (HLA) matching between couples or 
      between mothers and offspring have independently been associated with 
      prenatal/obstetric complications, including preeclampsia and low birth weight. 
      Here, we report the results of a family-based candidate-gene study that brings 
      together these two disparate lines of research by assessing maternal-fetal 
      genotype matching at HLA-A, -B, and -DRB1 as a risk factor of schizophrenia. We 
      used a conditional-likelihood modeling approach with a sample of 274 families 
      that had at least one offspring with schizophrenia or a related spectrum 
      disorder. A statistically significant HLA-B maternal-fetal genotype-matching 
      effect on schizophrenia was demonstrated for female offspring (P=.01; parameter 
      estimate 1.7 [95% confidence interval 1.22-2.49]). Because the matching effect 
      could be associated with pregnancy complications rather than with schizophrenia 
      per se, these findings are consistent with the neurodevelopmental hypothesis of 
      schizophrenia and with accumulating evidence that the prenatal period is involved 
      in the origins of this disease. Our approach demonstrates how genetic markers can 
      be used to characterize the biology of prenatal risk factors of schizophrenia.
FAU - Palmer, Christina G S
AU  - Palmer CG
AD  - Department of Psychiatry and Biobehavioral Sciences, University of California-Los 
      Angeles, Los Angeles, CA 90095, USA. cpalmer@mednet.ucla.edu
FAU - Hsieh, Hsin-Ju
AU  - Hsieh HJ
FAU - Reed, Elaine F
AU  - Reed EF
FAU - Lonnqvist, Jouko
AU  - Lonnqvist J
FAU - Peltonen, Leena
AU  - Peltonen L
FAU - Woodward, J Arthur
AU  - Woodward JA
FAU - Sinsheimer, Janet S
AU  - Sinsheimer JS
LA  - eng
GR  - R01 GM053275/GM/NIGMS NIH HHS/United States
GR  - R21 MH066001/MH/NIMH NIH HHS/United States
GR  - GM53275/GM/NIGMS NIH HHS/United States
GR  - MH066001/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20060815
PL  - United States
TA  - Am J Hum Genet
JT  - American journal of human genetics
JID - 0370475
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Female
MH  - Genotype
MH  - HLA Antigens/immunology
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Nuclear Family
MH  - Pregnancy
MH  - Pregnancy Complications/genetics/immunology
MH  - Risk Factors
MH  - Schizophrenia/*genetics/physiopathology
MH  - Sex Characteristics
PMC - PMC1592576
EDAT- 2006/09/09 09:00
MHDA- 2006/11/01 09:00
PMCR- 2007/04/01
CRDT- 2006/09/09 09:00
PHST- 2006/04/14 00:00 [received]
PHST- 2006/07/16 00:00 [accepted]
PHST- 2006/09/09 09:00 [pubmed]
PHST- 2006/11/01 09:00 [medline]
PHST- 2006/09/09 09:00 [entrez]
PHST- 2007/04/01 00:00 [pmc-release]
AID - S0002-9297(07)63081-X [pii]
AID - 43692 [pii]
AID - 10.1086/507829 [doi]
PST - ppublish
SO  - Am J Hum Genet. 2006 Oct;79(4):710-5. doi: 10.1086/507829. Epub 2006 Aug 15.