PMID- 16961267
OWN - NLM
STAT- MEDLINE
DCOM- 20080616
LR  - 20191110
IS  - 1672-0733 (Print)
IS  - 1672-0733 (Linking)
VI  - 26
IP  - 3
DP  - 2006
TI  - Different effects of capsaicin on I(A) and I(K) in pain-conduct neurons of rats.
PG  - 275-7
AB  - The different effects of capsaicin on I(A) and I(K) currents in pain-conduct 
      neurons of trigeminal ganglia (TG) were investigated. In cultured TG neurons of 
      rats, whole-cell patch clamp techniques were used to record the I(A) and I(K) 
      before and after capsaicin perfused. Results revealed that 1 micromol/L capsaicin 
      could inhibit the amplitude of I(A) by 48.2% (n = 10, P < 0.05), but had no 
      inhibitory effect on I(K) (n = 7, P > 0.05). Ten micromol/L capsaicin could 
      significantly inhibit the amplitude of I(A) by 93.2% (n = 8, P < 0.01), but only 
      slightly inhibit the amplitude of I(K) by 13.2% (n = 7, P < 0.05). Neither 1 
      micromol/L nor 10 micromol/L capsaicin had effects on the active curve of I(A) 
      and I(K). It was concluded that capsaicin could selectively inhibit the I(A) 
      current, and this effect might involve in the analgesic mechanisms of capsaicin.
FAU - Fu, Hui
AU  - Fu H
AD  - Department of Pharmacology, School of Basic Medical Sciences, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan 430030, China.
FAU - Liu, Hui
AU  - Liu H
FAU - Cao, Xuehong
AU  - Cao X
FAU - Hu, Yan
AU  - Hu Y
FAU - Xiang, Jizhou
AU  - Xiang J
FAU - Liu, Lieju
AU  - Liu L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - 0 (Potassium Channels, Voltage-Gated)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Animals
MH  - Capsaicin/*pharmacology
MH  - Cells, Cultured
MH  - Membrane Potentials/drug effects
MH  - Neurons/cytology/*drug effects/physiology
MH  - Nociceptors/*physiology
MH  - Patch-Clamp Techniques
MH  - Potassium Channels, Voltage-Gated/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Trigeminal Ganglion/cytology
EDAT- 2006/09/12 09:00
MHDA- 2008/06/17 09:00
CRDT- 2006/09/12 09:00
PHST- 2006/09/12 09:00 [pubmed]
PHST- 2008/06/17 09:00 [medline]
PHST- 2006/09/12 09:00 [entrez]
AID - 10.1007/BF02829549 [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2006;26(3):275-7. doi: 10.1007/BF02829549.