PMID- 16961271
OWN - NLM
STAT- MEDLINE
DCOM- 20080616
LR  - 20191110
IS  - 1672-0733 (Print)
IS  - 1672-0733 (Linking)
VI  - 26
IP  - 3
DP  - 2006
TI  - Expression of resistin protein in normal human subcutaneous adipose tissue and 
      pregnant women subcutaneous adipose tissue and placenta.
PG  - 288-91
AB  - The expression of resistin protein in normal human abdominal, thigh, pregnant 
      women abdominal, non-pregnant women abdominal subcutaneous adipose tissue and 
      placenta and the relationship between obesity, type 2 diabetes mellitus (T2DM), 
      pregnant physiological insulin resistance (IR) and gestational diabetes mellitus 
      (GDM) was investigated. The expression of resistin protein in normal human 
      abdominal, thigh, pregnant women abdominal, non-pregnant women abdominal 
      subcutaneous adipose tissue and placenta was detected by using Western blotting 
      method. Fasting serum glucose concentration was measured by glucose oxidase 
      assay. Serum cholesterol (CHOL), serum triglycerides (TG), serum HDL cholesterol 
      (HDL-C) and serum LDL cholesterol (LDL-C) were determined by full automatic 
      biochemical instrument. Fasting insulin was measured by enzyme immunoassay to 
      calculate insulin resistance index (IRI). Height, weight, systolic blood pressure 
      (SBP) and diastolic blood pressure (DBP) were measured to calculate body mass 
      index (BMI) and body fat percentage (BF %). Resistin protein expression in 
      pregnant women placental tissue (67 905 +/- 8441) (arbitrary A values) was much 
      higher than that in subcutaneous adipose tissue in pregnant women abdomen (40 718 
      +/- 3818, P < 0.01), non-pregnant women abdomen (38 288 +/- 2084, P < 0.01), 
      normal human abdomen (39 421 +/- 6087, P < 0.01) and thigh (14 942 +/- 6706, P < 
      0.001) respectively. The resistin expression in abdominal subcutaneous adipose 
      tissue showed no significant difference among pregnant, non-pregnant women and 
      normal human, but much higher than that in thigh subcutaneous adipose tissue (P < 
      0.001). Pearson analysis revealed that resistin protein was correlated with BMI 
      (r = 0.42), fasting insulin concentration (r = 0.38), IRI (r = 0.34), BF % (r = 
      0.43) and fasting glucose (r = 0.39), but not with blood pressure, CHOL, TG, 
      HDL-C and LDL-C. It was suggested that resistin protein expression in human 
      abdominal subcutaneous adipose tissue was much higher than that in human thigh 
      subcutaneous adipose tissue. Resistin was closely related with central obesity, 
      leading to IR, subsequently obesity and T2DM. Resistin protein expression in 
      placental tissue was much higher than that in subcutaneous adipose tissue in 
      normal human abdomen, pregnant abdomen, non-pregnant women abdomen and thigh. It 
      was indicated that resistin protein could be secreted from human placental 
      tissue. Resistin might be one of the factors that lead to pregnant physiological 
      IR and GDM.
FAU - Zhou, Yongming
AU  - Zhou Y
AD  - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, China.
FAU - Zhang, Muxun
AU  - Zhang M
FAU - Guo, Wei
AU  - Guo W
FAU - Yu, Meixia
AU  - Yu M
FAU - Xue, Keying
AU  - Xue K
FAU - Huang, Shiang
AU  - Huang S
FAU - Chen, Yanhong
AU  - Chen Y
FAU - Zhu, Huanli
AU  - Zhu H
FAU - Xu, Lijun
AU  - Xu L
FAU - Guo, Tiecheng
AU  - Guo T
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 0 (Resistin)
SB  - IM
MH  - Blood Glucose/metabolism
MH  - Blotting, Western
MH  - Fasting/blood
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Lipids/blood
MH  - Male
MH  - Obesity/blood
MH  - Placenta/*metabolism
MH  - Pregnancy
MH  - Pregnancy Complications/metabolism
MH  - Radioimmunoassay
MH  - Resistin/*biosynthesis
MH  - Subcutaneous Fat/*metabolism
EDAT- 2006/09/12 09:00
MHDA- 2008/06/17 09:00
CRDT- 2006/09/12 09:00
PHST- 2006/09/12 09:00 [pubmed]
PHST- 2008/06/17 09:00 [medline]
PHST- 2006/09/12 09:00 [entrez]
AID - 10.1007/BF02829553 [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2006;26(3):288-91. doi: 
      10.1007/BF02829553.