PMID- 16962375
OWN - NLM
STAT- MEDLINE
DCOM- 20070118
LR  - 20210102
IS  - 1471-4914 (Print)
IS  - 1471-4914 (Linking)
VI  - 12
IP  - 10
DP  - 2006 Oct
TI  - MHC-peptide specificity and T-cell epitope mapping: where immunotherapy starts.
PG  - 465-72
AB  - The evaluation and characterization of epitope-specific human leukocyte antigen 
      (HLA)-restricted memory T-cell reactivity is an important step for the 
      development of preventive vaccines and peptide-based immunotherapies for viral 
      and tumor diseases. The past decade has witnessed the use of HLA-restricted 
      peptides as tools to activate strong immune responses of naive or memory T cells 
      specifically. This has fuelled an active search for methodological approaches 
      focusing on HLA and peptide associations. Here, we outline new perspective on the 
      emerging opportunity of evaluating HLA and peptide restriction by using novel 
      approaches, such as quantitative real-time PCR, that can identify epitope 
      specificities that are potentially useful in clinical settings.
FAU - Provenzano, Maurizio
AU  - Provenzano M
AD  - Institute for Surgical Research and Hospital Management, University of Basel, 
      4031 Basel, Switzerland. mprovenzano@uhbs.ch
FAU - Panelli, Monica C
AU  - Panelli MC
FAU - Mocellin, Simone
AU  - Mocellin S
FAU - Bracci, Laura
AU  - Bracci L
FAU - Sais, Giovanni
AU  - Sais G
FAU - Stroncek, David F
AU  - Stroncek DF
FAU - Spagnoli, Giulio C
AU  - Spagnoli GC
FAU - Marincola, Francesco M
AU  - Marincola FM
LA  - eng
PT  - Journal Article
DEP - 20060907
PL  - England
TA  - Trends Mol Med
JT  - Trends in molecular medicine
JID - 100966035
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (HLA Antigens)
RN  - 0 (Peptides)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - *Epitope Mapping
MH  - Epitopes, T-Lymphocyte/*immunology
MH  - HLA Antigens/therapeutic use
MH  - Humans
MH  - Immunologic Memory
MH  - *Immunotherapy
MH  - *Major Histocompatibility Complex
MH  - Models, Biological
MH  - Peptides/*immunology
MH  - Polymerase Chain Reaction
MH  - Signal Transduction/physiology
MH  - Substrate Specificity
EDAT- 2006/09/12 09:00
MHDA- 2007/01/19 09:00
CRDT- 2006/09/12 09:00
PHST- 2006/04/21 00:00 [received]
PHST- 2006/08/04 00:00 [revised]
PHST- 2006/08/24 00:00 [accepted]
PHST- 2006/09/12 09:00 [pubmed]
PHST- 2007/01/19 09:00 [medline]
PHST- 2006/09/12 09:00 [entrez]
AID - S1471-4914(06)00195-X [pii]
AID - 10.1016/j.molmed.2006.08.008 [doi]
PST - ppublish
SO  - Trends Mol Med. 2006 Oct;12(10):465-72. doi: 10.1016/j.molmed.2006.08.008. Epub 
      2006 Sep 7.