PMID- 16969095
OWN - NLM
STAT- MEDLINE
DCOM- 20070108
LR  - 20200930
IS  - 1538-4047 (Print)
IS  - 1538-4047 (Linking)
VI  - 5
IP  - 8
DP  - 2006 Aug
TI  - Lysyl oxidase (LOX) and hypoxia-induced metastases.
PG  - 909-11
AB  - Angiogenesis is a critical process in the transition of tumors from a localized, 
      primary site to a distant site of metastases. Hypoxic conditions within the tumor 
      mass lead to the activation of signalling pathways which initiate tumor cell 
      invasion, migration, adhesion and subsequent angiogenesis. Several key molecular 
      players in hypoxia-induced tumor progression are well-described, e.g., 
      hypoxia-inducible factor-1 (HIF-1) and angiopoietin-2; however, drug development 
      aimed at suppressing individual members of this signalling cascade has proven to 
      be challenging. The article by Erler et al. published in Nature (Vol. 440, April 
      2006) identifies lysyl oxidase (LOX) as an essential enzyme for hypoxia-induced 
      metastases. This Journal Club reviews the findings presented by Erler and 
      colleagues and briefly discusses the implications of LOX in cancer.
FAU - Sion, Amy M
AU  - Sion AM
AD  - Clinical Pharmacology Program, Medical Oncology Branch, Center for Cancer 
      Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
FAU - Figg, William D
AU  - Figg WD
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060826
PL  - United States
TA  - Cancer Biol Ther
JT  - Cancer biology & therapy
JID - 101137842
RN  - EC 1.4.3.13 (Protein-Lysine 6-Oxidase)
SB  - IM
MH  - Animals
MH  - *Cell Hypoxia
MH  - Humans
MH  - Neoplasm Metastasis/*pathology
MH  - Neoplasms/*enzymology/pathology
MH  - Protein-Lysine 6-Oxidase/antagonists & inhibitors/*metabolism
RF  - 12
EDAT- 2006/09/14 09:00
MHDA- 2007/01/09 09:00
CRDT- 2006/09/14 09:00
PHST- 2006/09/14 09:00 [pubmed]
PHST- 2007/01/09 09:00 [medline]
PHST- 2006/09/14 09:00 [entrez]
AID - 3230 [pii]
AID - 10.4161/cbt.5.8.3230 [doi]
PST - ppublish
SO  - Cancer Biol Ther. 2006 Aug;5(8):909-11. doi: 10.4161/cbt.5.8.3230. Epub 2006 Aug 
      26.