PMID- 16970094
OWN - NLM
STAT- MEDLINE
DCOM- 20080103
LR  - 20161018
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 26
IP  - 8
DP  - 2006 Aug
TI  - [Experimental study on effects of electro-acupuncture in improving synaptic 
      plasticity in focal cerebral ischemia rats].
PG  - 710-4
AB  - OBJECTIVE: To explore the mechanisms of electro-acupuncture (EA) in improving 
      synaptic plasticity after cerebral ischemic injury. METHODS: Focal cerebral 
      ischemia (FCI) model was established by middle cerebral artery occlusion (MCAO) 
      with heat-coagulation method. The changing rules of synaptic ultrastructure, 
      synaptophysin (P38), growth-associated protein-43 (GAP-43), brain-derived 
      neurotrophic factor (BDNF) and nerve growth factor (NGF) in the ischemic cortex 2 
      and 5 weeks after FCI and the effects of EA on them were observed. RESULTS: 
      Expression of numerical density (Nv), surface density (Sv), volume density (Vv), 
      post synaptic density (PSD) and P38 in the ischemic cortex significantly 
      decreased after MCAO (P<0.01). Among them, Nv and Sv were raised at the 5th week 
      in FCI rats either treated or untreated with EA (P<0.01), but the increment of Sv 
      was higher in those of the treated rats (P<0.01); PSD in the EA treated rats also 
      showed a significant increase at the 5th week, which was significant higher than 
      that in those untreated; EA showed insignificant influence on Vv and synaptic 
      interfacial curvature; P38 lowered continuously after 2 weeks, but at the 5th 
      week, it was higher in EA treated rats than that in untreated rats (P<0.01), 
      while at the 2nd week, the levels in treated and untreated rats were equal. 
      GAP-43 rose in the 2nd week after modeling, with no difference between EA treated 
      and untreated animals, at the 5th week, it was lowered in untreated rats to near 
      that in sham-operated rats, but maintained at higher level in EA treated rats; 
      NGF and BDNF positive cells significantly increased after modeling (P<0.01), and 
      showed a descending trend with the time going (P<0.01) both in rats treated or 
      untreated with EA. CONCLUSION: EA can protect synaptic ultrastructure, promote 
      the expression of P38, GAP-43, NGF and BDNF in the ischemic cerebral cortex, and 
      thus improve synaptic plasticity in cerebral ischemic rats.
FAU - Yi, Wei
AU  - Yi W
AD  - Guangzhou University of TCM, Guangzhou 510405. yw8013@tom.com
FAU - Xu, Neng-gui
AU  - Xu NG
FAU - Wang, Guo-bin
AU  - Wang GB
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
SB  - IM
MH  - Acupuncture Therapy
MH  - Animals
MH  - *Electroacupuncture
MH  - Female
MH  - Infarction, Middle Cerebral Artery/physiopathology/*therapy
MH  - Male
MH  - *Neuronal Plasticity
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Synapses/*physiology
EDAT- 2006/09/15 09:00
MHDA- 2008/01/04 09:00
CRDT- 2006/09/15 09:00
PHST- 2006/09/15 09:00 [pubmed]
PHST- 2008/01/04 09:00 [medline]
PHST- 2006/09/15 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Aug;26(8):710-4.