PMID- 16970270
OWN - NLM
STAT- MEDLINE
DCOM- 20061026
LR  - 20190117
IS  - 1726-4901 (Print)
IS  - 1726-4901 (Linking)
VI  - 69
IP  - 8
DP  - 2006 Aug
TI  - Evaluation of the associations between the single nucleotide polymorphisms of the 
      promoter region of the tumor necrosis factor-alpha gene and nasopharyngeal 
      carcinoma.
PG  - 351-7
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is a pro-inflammatory 
      cytokine and may act as an endogenous tumor promoter. Single nucleotide 
      polymorphisms (SNPs) of the TNF-alpha gene promoter region have been found to be 
      associated with certain cancers. We conducted a case-control study to evaluate 
      the association between these SNPs and nasopharyngeal carcinoma (NPC). METHODS: 
      We used polymerase chain reaction followed by restriction fragment length 
      polymorphism analysis to determine the -308 TNF-alpha promoter genotypes of 89 
      NPC patients and 360 healthy controls. In 23 NPC patients and 50 controls, we 
      determined the sequence from -1065 to -101 nucleotides of the TNF-alpha gene 
      promoter region to detect SNPs. RESULTS: In comparison with the controls, the NPC 
      patients had higher proportions of men and carriage of IgA antibodies against the 
      capsid antigen of Epstein-Barr virus, but had a similar carrier rate of the -308A 
      allele (odds ratio [OR], 1.2; 95% confidence interval [CI], 0.7-2.0). The 
      carriage of the -308A allele was not associated with the occurrence of NPC in 
      comparison with -308G homozygosity. We also found no significant differences in 
      the distributions of allelic variants of the -1031, -863, -857, and -806 loci of 
      the TNF-alpha promoter region, but observed a lower carrier rate of the novel 
      -806T allele in the NPC patients (OR, 0.3; 95% Cl, 0.0-2.9). CONCLUSION: Allelic 
      variants of the TNF-alpha promoter gene may not be used as biomarkers of 
      susceptibility to NPC. The role of the -806T allele needs to be studied further.
FAU - Ho, Sheng-Yow
AU  - Ho SY
AD  - Department of Radiation Oncology, Sin-Lau Christian Hospital, Taiwan, ROC.
FAU - Wang, Ying-Jan
AU  - Wang YJ
FAU - Huang, Po-Chang
AU  - Huang PC
FAU - Tsai, Sen-Tien
AU  - Tsai ST
FAU - Chen, Chih-Hung
AU  - Chen CH
FAU - Chen, Helen H W
AU  - Chen HH
FAU - Chang, Chih-Jen
AU  - Chang CJ
FAU - Guo, How-Ran
AU  - Guo HR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Chin Med Assoc
JT  - Journal of the Chinese Medical Association : JCMA
JID - 101174817
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Neoplasms/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2006/09/15 09:00
MHDA- 2006/10/27 09:00
CRDT- 2006/09/15 09:00
PHST- 2006/09/15 09:00 [pubmed]
PHST- 2006/10/27 09:00 [medline]
PHST- 2006/09/15 09:00 [entrez]
AID - S1726-4901(09)70272-2 [pii]
AID - 10.1016/S1726-4901(09)70272-2 [doi]
PST - ppublish
SO  - J Chin Med Assoc. 2006 Aug;69(8):351-7. doi: 10.1016/S1726-4901(09)70272-2.