PMID- 16970955
OWN - NLM
STAT- MEDLINE
DCOM- 20070717
LR  - 20111117
IS  - 0021-9150 (Print)
IS  - 0021-9150 (Linking)
VI  - 192
IP  - 2
DP  - 2007 Jun
TI  - Ethanol beverages containing polyphenols decrease nuclear factor kappa-B 
      activation in mononuclear cells and circulating MCP-1 concentrations in healthy 
      volunteers during a fat-enriched diet.
PG  - 335-41
AB  - AIMS: Different epidemiological studies have demonstrated that some ethanol 
      containing beverages intake could be associated with a reduction of 
      cardiovascular mortality, effect attributed in part to its antioxidant 
      properties. Nuclear factor-kappa B (NF-kappaB) is a redox sensitive transcription 
      factor implicated in the pathogenesis of atherosclerosis. We have examined the 
      effect of four different ethanol containing beverages on the activation of 
      NF-kappaB in peripheral blood mononuclear cells (PBMC) and circulating 
      concentrations of monocyte chemoattractant protein-1 (MCP-1) in healthy 
      volunteers receiving a fat-enriched diet. METHODS AND RESULTS: Sixteen volunteers 
      received 16 g/m(2) of ethanol in form of red wine, spirits (vodka, rum, and 
      brandy) or no ethanol intake along with a fat-enriched diet during 5 days and all 
      of them took all alcohols at different periods. NF-kappaB activation 
      (electrophoretic mobility shift assay) and circulating MCP-1 levels (ELISA) were 
      examined in blood samples taken before and after 5 days of ethanol intake. 
      Subjects receiving a fat-enriched diet had increased NF-kappaB activation in PBMC 
      at day 5. Furthermore, MCP-1 levels were increased in plasma at day 5. Red wine 
      intake and some ethanol beverages containing polyphenols (brandy and rum) 
      prevented NF-kappaB activation and decreased MCP-1 release. CONCLUSION: 
      Consumption of moderate amounts of alcoholic drinks containing polyphenols 
      decreases NF-kappaB activation in PBMCs and MCP-1 plasma levels during a 
      fat-enriched diet. Our results provide additional evidence of the 
      anti-inflammatory effects of some ethanol containing beverages, further 
      supporting the idea that its moderate consumption may help to reduce overall 
      cardiovascular mortality.
FAU - Blanco-Colio, Luis Miguel
AU  - Blanco-Colio LM
AD  - Vascular Research Laboratory, Fundacion Jimenez Diaz, Autonoma University, 
      Avenida Reyes Catolicos 2, Madrid, Spain.
FAU - Munoz-Garcia, Begona
AU  - Munoz-Garcia B
FAU - Martin-Ventura, Jose Luis
AU  - Martin-Ventura JL
FAU - Alvarez-Sala, Luis Antonio
AU  - Alvarez-Sala LA
FAU - Castilla, Manuela
AU  - Castilla M
FAU - Bustamante, Ana
AU  - Bustamante A
FAU - Lamuela-Raventos, Rosa Maria
AU  - Lamuela-Raventos RM
FAU - Gomez-Gerique, Juan
AU  - Gomez-Gerique J
FAU - Fernandez-Cruz, Arturo
AU  - Fernandez-Cruz A
FAU - Millan, Jesus
AU  - Millan J
FAU - Egido, Jesus
AU  - Egido J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060912
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Dietary Fats)
RN  - 0 (Flavonoids)
RN  - 0 (NF-kappa B)
RN  - 0 (Phenols)
RN  - 0 (Polyphenols)
SB  - IM
MH  - Adult
MH  - *Alcoholic Beverages
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Chemokine CCL2/*blood
MH  - Dietary Fats/*administration & dosage
MH  - Female
MH  - Flavonoids/*pharmacology
MH  - Humans
MH  - Leukocytes, Mononuclear/*drug effects/physiology
MH  - Male
MH  - NF-kappa B/drug effects/*metabolism
MH  - Phenols/*pharmacology
MH  - Polyphenols
EDAT- 2006/09/15 09:00
MHDA- 2007/07/18 09:00
CRDT- 2006/09/15 09:00
PHST- 2006/05/04 00:00 [received]
PHST- 2006/07/25 00:00 [revised]
PHST- 2006/07/28 00:00 [accepted]
PHST- 2006/09/15 09:00 [pubmed]
PHST- 2007/07/18 09:00 [medline]
PHST- 2006/09/15 09:00 [entrez]
AID - S0021-9150(06)00463-1 [pii]
AID - 10.1016/j.atherosclerosis.2006.07.035 [doi]
PST - ppublish
SO  - Atherosclerosis. 2007 Jun;192(2):335-41. doi: 
      10.1016/j.atherosclerosis.2006.07.035. Epub 2006 Sep 12.