PMID- 16973931
OWN - NLM
STAT- MEDLINE
DCOM- 20070208
LR  - 20220227
IS  - 0363-6119 (Print)
IS  - 0363-6119 (Linking)
VI  - 292
IP  - 1
DP  - 2007 Jan
TI  - Transient receptor potential ion channels as participants in thermosensation and 
      thermoregulation.
PG  - R64-76
AB  - Living organisms must evaluate changes in environmental and internal temperatures 
      to mount appropriate physiological and behavioral responses conducive to 
      survival. Classical physiology has provided a wealth of information regarding the 
      specialization of thermosensory functions among subclasses of peripheral sensory 
      neurons and intrinsically thermosensitive neurons within the hypothalamus. 
      However, until recently, the molecular mechanisms by which these cells carry out 
      thermometry have remained poorly understood. The demonstration that certain ion 
      channels of the transient receptor potential (TRP) family can be activated by 
      increases or decreases in ambient temperature, along with the recognition of 
      their heterogeneous expression patterns and heterogeneous temperature 
      sensitivities, has led investigators to evaluate these proteins as candidate 
      endogenous thermosensors. Much of this work has involved one specific channel, 
      TRP vanilloid 1 (TRPV1), which is both a receptor for capsaicin and related 
      pungent vanilloid compounds and a "heat receptor," capable of directly 
      depolarizing neurons in response to temperatures >42 degrees C. Evidence for a 
      contribution of TRPV1 to peripheral thermosensation has come from 
      pharmacological, physiological, and genetic approaches. In contrast, although 
      capsaicin-sensitive mechanisms clearly influence core body temperature 
      regulation, the specific contribution of TRPV1 to this process remains a matter 
      of debate. Besides TRPV1, at least six additional thermally sensitive TRP 
      channels have been identified in mammals, and many of these also appear to 
      participate in thermosensation. Moreover, the identification of invertebrate TRP 
      channels, whose genetic ablation alters thermally driven behaviors, makes it 
      clear that thermosensation represents an evolutionarily conserved role of this 
      ion channel family.
FAU - Caterina, Michael J
AU  - Caterina MJ
AD  - Department of Biological Chemistry, Center for Sensory Biology, Johns Hopkins 
      School of Medicine, 725 N. Wolfe St., Baltimore, MD 21205, USA. caterina@jhmi.edu
LA  - eng
GR  - NS051551-05/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20060914
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 0 (TRPV Cation Channels)
RN  - 0 (TRPV1 receptor)
RN  - 0 (Transient Receptor Potential Channels)
SB  - IM
MH  - Animals
MH  - Body Temperature Regulation/genetics/*physiology
MH  - Humans
MH  - Mice
MH  - Mice, Knockout
MH  - TRPV Cation Channels/physiology
MH  - Thermosensing/genetics/*physiology
MH  - Transient Receptor Potential Channels/genetics/*physiology
RF  - 165
EDAT- 2006/09/16 09:00
MHDA- 2007/02/09 09:00
CRDT- 2006/09/16 09:00
PHST- 2006/09/16 09:00 [pubmed]
PHST- 2007/02/09 09:00 [medline]
PHST- 2006/09/16 09:00 [entrez]
AID - 00446.2006 [pii]
AID - 10.1152/ajpregu.00446.2006 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R64-76. doi: 
      10.1152/ajpregu.00446.2006. Epub 2006 Sep 14.