PMID- 16978536
OWN - NLM
STAT- MEDLINE
DCOM- 20070112
LR  - 20060918
IS  - 1672-7681 (Print)
IS  - 1672-7681 (Linking)
VI  - 3
IP  - 4
DP  - 2006 Aug
TI  - DC-SIGN and immunoregulation.
PG  - 279-83
AB  - Dendritic cells (DCs) are known to be the most powerful professional 
      antigen-presenting cells so far. It could activate primary immune response, and 
      also downregulate immune response. DCs have a unique character of 
      immunoregulation. DC-SIGN, a molecule designated as CD209, is one member of the 
      C-type lectin superfamily. It is not only a pattern recognition receptor but 
      implicated in immunoregulation of DCs. DC-SIGN has become hotspot of recent 
      studies because of its important role in mediating DC adhesion, migration, 
      inflammation, activating primary T cell, triggering immune response and 
      participating in immune escape of pathogens and tumors. These studies on DC-SIGN 
      involved in primary and secondary immune response and relevant mechanism will 
      certainly provide us with a new method in treating and preventing certain 
      diseases.
FAU - Zhou, Tong
AU  - Zhou T
AD  - Department of Nephrology, Ruijin Hospital Affiliated to Shanghai Jiaotong 
      University, School of Medicine, Shanghai 200025, China. zhoutong_cn@hotmail.com
FAU - Chen, Yongxi
AU  - Chen Y
FAU - Hao, Li
AU  - Hao L
FAU - Zhang, Yanyun
AU  - Zhang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Cell Mol Immunol
JT  - Cellular & molecular immunology
JID - 101242872
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Pattern Recognition)
SB  - IM
MH  - Cell Adhesion Molecules/chemistry/*physiology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - *Immunity
MH  - Lectins, C-Type/chemistry/*physiology
MH  - Receptors, Cell Surface/chemistry/*physiology
MH  - Receptors, Pattern Recognition/immunology
MH  - Tumor Escape/immunology
RF  - 43
EDAT- 2006/09/19 09:00
MHDA- 2007/01/16 09:00
CRDT- 2006/09/19 09:00
PHST- 2006/09/19 09:00 [pubmed]
PHST- 2007/01/16 09:00 [medline]
PHST- 2006/09/19 09:00 [entrez]
PST - ppublish
SO  - Cell Mol Immunol. 2006 Aug;3(4):279-83.