PMID- 16978760
OWN - NLM
STAT- MEDLINE
DCOM- 20061113
LR  - 20220310
IS  - 0300-483X (Print)
IS  - 0300-483X (Linking)
VI  - 227
IP  - 3
DP  - 2006 Oct 29
TI  - Deltamethrin-induced oxidative damage and biochemical alterations in rat and its 
      attenuation by Vitamin E.
PG  - 240-7
AB  - Deltamethrin is a synthetic pyrethroid insecticide used worldwide in agriculture, 
      home pest control, protection of foodstuff and disease vector control. The 
      objective of this study was to investigate the propensity of deltamethrin to 
      induce oxidative stress and changes in biochemical parameters and enzyme 
      activities in male rats following a short-term (30 days) oral exposure and its 
      possible attenuation by Vitamin E (Vit. E). Rats were assigned to 1 of 4 
      treatment groups: 0mg Vit. E and 0mg deltamethrin/kg body weight (BW) (control); 
      100mg Vit. E/kg BW; 1.28mg deltamethrin/kg BW; 100mg Vit. E plus 1.28mg 
      deltamethrin/kg BW. Results obtained showed that deltamethrin significantly 
      (P<0.05) induced thiobarbituric acid-reactive substances (TBARS; the marker of 
      lipid peroxidation) in plasma. The activities of glutathione S-transferase (GST) 
      and superoxide dismutase (SOD) were significantly decreased due to deltamethrin 
      administration. On the other hand, treatment with Vitamin E alone increased the 
      activities of GST and SOD, and decreased the levels of TBARS. Also, Vitamin E 
      alleviated the harmful effect of deltamethrin in the combination group. Enzymatic 
      activities of aminotransferases (AST and ALT), phosphatases (AcP and AlP) and 
      lactate dehydrogenase (LDH) in plasma were significantly increased, while 
      acetylcholinesterase (AChE) was inhibited. Deltamethrin significantly (P<0.05) 
      increased the levels of plasma total lipid (TL), cholesterol, triglyceride (TG), 
      low density lipoprotein (LDL) and very low density lipoprotein (VLDL), while the 
      level of high density lipoprotein (HDL) decreased. Vitamin E alone decreased the 
      levels of lipids and lipoproteins, and alleviated the harmful effects of 
      deltamethrin. Concentrations of glucose, urea, creatinine and total bilirubin 
      were increased. While, plasma total protein (TP), albumin (A) and globulin (G) 
      were significantly (P<0.05) decreased. The present study revealed that the 
      presence of Vitamin E could diminish the adverse effects of deltamethrin on most 
      of biochemical parameters, lipid peroxidation and enzyme activities in rats.
FAU - Yousef, Mokhtar I
AU  - Yousef MI
AD  - Department of Environmental Studies, Institute of Graduate Studies and Research, 
      Alexandria University, 163, Horreya Avenue, P.O. Box 832, Alexandria 21526, 
      Egypt. mokhtar_yousef@yahoo.com
FAU - Awad, Talaat I
AU  - Awad TI
FAU - Mohamed, Edriss H
AU  - Mohamed EH
LA  - eng
PT  - Journal Article
DEP - 20060814
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (Antioxidants)
RN  - 0 (Enzymes)
RN  - 0 (Insecticides)
RN  - 0 (Lipids)
RN  - 0 (Nitriles)
RN  - 0 (Pyrethrins)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 1406-18-4 (Vitamin E)
RN  - 2JTS8R821G (decamethrin)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Enzymes/blood
MH  - Insecticides/*toxicity
MH  - Lipid Peroxidation/*drug effects
MH  - Lipids/blood
MH  - Male
MH  - Nitriles/*toxicity
MH  - Oxidative Stress/*drug effects
MH  - Pyrethrins/*toxicity
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Thiobarbituric Acid Reactive Substances/analysis
MH  - Vitamin E/*pharmacology
EDAT- 2006/09/19 09:00
MHDA- 2006/11/14 09:00
CRDT- 2006/09/19 09:00
PHST- 2006/05/31 00:00 [received]
PHST- 2006/08/03 00:00 [revised]
PHST- 2006/08/08 00:00 [accepted]
PHST- 2006/09/19 09:00 [pubmed]
PHST- 2006/11/14 09:00 [medline]
PHST- 2006/09/19 09:00 [entrez]
AID - S0300-483X(06)00502-6 [pii]
AID - 10.1016/j.tox.2006.08.008 [doi]
PST - ppublish
SO  - Toxicology. 2006 Oct 29;227(3):240-7. doi: 10.1016/j.tox.2006.08.008. Epub 2006 
      Aug 14.