PMID- 16979157
OWN - NLM
STAT- MEDLINE
DCOM- 20070130
LR  - 20131121
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 549
IP  - 1-3
DP  - 2006 Nov 7
TI  - Aldose reductase inhibitor zopolrestat restores allergic hyporesponsiveness in 
      alloxan-diabetic rats.
PG  - 173-8
AB  - This study was undertaken to investigate the role of the aldose reductase in the 
      refractoriness of diabetic rats to allergic inflammation. Wistar rats were 
      actively sensitized with a mixture of Al(OH)3 plus ovalbumin and intrapleurally 
      challenged with ovalbumin, 14 days later. Diabetes was induced by intravenous 
      injection of alloxan into fasted rats, 7 days before sensitization, and the 
      aldose reductase inhibitor zopolrestat was administered after 3 days of diabetes 
      induction, once a day during 18 consecutive days. The treatment with zopolrestat 
      restored antigen-induced protein extravazation and mast cell degranulation in the 
      pleural cavity of diabetic sensitized rats. Zopolrestat also significantly 
      reversed the suppression in the increase of total and specific levels of serum 
      immunoglobulin E (IgE) noted in sensitized animals under conditions of diabetes. 
      In addition, we noted that the drop in the pleural mast cell numbers as well as 
      the increase in serum corticosterone levels in diabetic rats were inhibited by 
      the drug. Our findings show that zopolrestat restored the hyporesponsiveness of 
      diabetic rats to antigen provocation, in parallel with impairment of 
      alloxan-induced mast cell depletion and hypercorticolism, indicating that polyol 
      pathway activity seems to play an important role in these phenomena.
FAU - Carvalho, Vinicius F
AU  - Carvalho VF
AD  - Laboratorio de Inflamacao, Departamento de Fisiologia e Farmacodinamica, 
      Instituto Oswaldo Cruz, FIOCRUZ, Av. Brasil, no 4365, Manguinhos, CEP 21045-900, 
      Rio de Janeiro, Brazil.
FAU - Barreto, Emiliano O
AU  - Barreto EO
FAU - Serra, Magda F
AU  - Serra MF
FAU - Cordeiro, Renato S B
AU  - Cordeiro RS
FAU - Martins, Marco A
AU  - Martins MA
FAU - Fortes, Zuleica Bruno
AU  - Fortes ZB
FAU - e Silva, Patricia M R
AU  - e Silva PM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060826
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Benzothiazoles)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Insulin)
RN  - 0 (Phthalazines)
RN  - 0 (Proteins)
RN  - 1PV3S9WP3D (zopolrestat)
RN  - 5QB0T2IUN0 (Aluminum Hydroxide)
RN  - 6SW5YHA5NG (Alloxan)
RN  - 9006-59-1 (Ovalbumin)
RN  - EC 1.1.1.21 (Aldehyde Reductase)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Aldehyde Reductase/*antagonists & inhibitors/metabolism
MH  - Alloxan
MH  - Aluminum Hydroxide/immunology
MH  - Animals
MH  - Benzothiazoles/*pharmacology
MH  - Cell Count
MH  - Cell Degranulation/drug effects
MH  - Corticosterone/blood
MH  - Diabetes Mellitus, Experimental/blood/chemically induced/*physiopathology
MH  - Hypersensitivity/immunology/*physiopathology/prevention & control
MH  - Hypoglycemic Agents/pharmacology
MH  - Immunoglobulin G/blood
MH  - Insulin/blood
MH  - Male
MH  - Mast Cells/cytology/drug effects/physiology
MH  - Ovalbumin/immunology
MH  - Phthalazines/*pharmacology
MH  - Pleural Cavity/cytology/drug effects/metabolism
MH  - Proteins/metabolism
MH  - Rats
MH  - Rats, Wistar
EDAT- 2006/09/19 09:00
MHDA- 2007/01/31 09:00
CRDT- 2006/09/19 09:00
PHST- 2006/02/23 00:00 [received]
PHST- 2006/08/07 00:00 [revised]
PHST- 2006/08/14 00:00 [accepted]
PHST- 2006/09/19 09:00 [pubmed]
PHST- 2007/01/31 09:00 [medline]
PHST- 2006/09/19 09:00 [entrez]
AID - S0014-2999(06)00883-1 [pii]
AID - 10.1016/j.ejphar.2006.08.037 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2006 Nov 7;549(1-3):173-8. doi: 10.1016/j.ejphar.2006.08.037. 
      Epub 2006 Aug 26.