PMID- 16979896
OWN - NLM
STAT- MEDLINE
DCOM- 20070202
LR  - 20071203
IS  - 0968-0896 (Print)
IS  - 0968-0896 (Linking)
VI  - 14
IP  - 24
DP  - 2006 Dec 15
TI  - New bisanthraquinone antibiotics and semi-synthetic derivatives with potent 
      activity against clinical Staphylococcus aureus and Enterococcus faecium 
      isolates.
PG  - 8446-54
AB  - The escalation of antibiotic resistance among Gram-positive pathogens presents 
      increasing treatment challenges and requires the development of innovative 
      therapeutic agents. Here, we present the antimicrobial properties of structurally 
      unusual bisanthraquinone metabolites produced by a marine streptomycete and four 
      semi-synthetic derivatives. Biological activities were measured against 
      clinically derived isolates of vancomycin-resistant Enterococcus faecium (VRE), 
      and methicillin-susceptible, methicillin-resistant, and tetracycline-resistant 
      Staphylococcus aureus (MSSA, MRSA, and TRSA, respectively). The most potent 
      antibiotic displayed MIC(50) values of 0.11, 0.23, and 0.90microM against a panel 
      (n=25 each) of clinical MSSA, MRSA, and VRE, respectively, and was determined to 
      be bactericidal by time-kill analysis.
FAU - Socha, Aaron M
AU  - Socha AM
AD  - Department of Biomedical, University of Rhode Island, 53 Fogarty Hall Kingston, 
      RI 02881, USA.
FAU - LaPlante, Kerry L
AU  - LaPlante KL
FAU - Rowley, David C
AU  - Rowley DC
LA  - eng
GR  - P20 RR016457/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20060918
PL  - England
TA  - Bioorg Med Chem
JT  - Bioorganic & medicinal chemistry
JID - 9413298
RN  - 0 (Anthraquinones)
RN  - 0 (Anti-Bacterial Agents)
RN  - 11006-76-1 (Virginiamycin)
SB  - IM
MH  - Anthraquinones/chemistry/isolation & purification/*pharmacology
MH  - Anti-Bacterial Agents/chemistry/isolation & purification/*pharmacology
MH  - Cells, Cultured/drug effects
MH  - Enterococcus faecium/*drug effects
MH  - Gram-Positive Bacterial Infections/*drug therapy/microbiology
MH  - Humans
MH  - Methicillin Resistance
MH  - Microbial Sensitivity Tests
MH  - Staphylococcal Infections/*drug therapy/microbiology
MH  - Staphylococcus aureus/*drug effects
MH  - Tetracycline Resistance
MH  - Vancomycin Resistance
MH  - Virginiamycin
EDAT- 2006/09/19 09:00
MHDA- 2007/02/03 09:00
CRDT- 2006/09/19 09:00
PHST- 2006/08/01 00:00 [received]
PHST- 2006/08/24 00:00 [revised]
PHST- 2006/08/28 00:00 [accepted]
PHST- 2006/09/19 09:00 [pubmed]
PHST- 2007/02/03 09:00 [medline]
PHST- 2006/09/19 09:00 [entrez]
AID - S0968-0896(06)00711-5 [pii]
AID - 10.1016/j.bmc.2006.08.038 [doi]
PST - ppublish
SO  - Bioorg Med Chem. 2006 Dec 15;14(24):8446-54. doi: 10.1016/j.bmc.2006.08.038. Epub 
      2006 Sep 18.