PMID- 16980244
OWN - NLM
STAT- MEDLINE
DCOM- 20061218
LR  - 20091117
IS  - 1556-9527 (Print)
IS  - 1556-9527 (Linking)
VI  - 25
IP  - 3
DP  - 2006
TI  - Hydrocarbon-based weapons maintenance compounds produce evidence of contact 
      hypersensitivity in BALB/c mice.
PG  - 185-94
AB  - Unprotected dermal contact with weapons maintenance materials is highly probable 
      during cleaning and maintenance of firearms. Several weapons maintenance 
      materials of interest to the Department of Defense were evaluated for their 
      irritating and sensitizing potential in a modified local lymph node assay (LLNA). 
      Female BALB/c mice (n = 5) were topically exposed to Break-Free CLP, Royco 634, 
      TW-25B, MC-25, or MC-2500. All compounds tested produced a positive response for 
      irritancy and lymphocyte proliferation. Break-Free CLP and Royco 634 produced the 
      greatest dermal irritation and highest LLNA stimulation index. Phenotyping of 
      draining lymph node cells from animals treated with Break-Free CLP suggest that 
      this material induces T-cell-mediated contact sensitization (Type IV 
      hypersensitivity) in mice. These findings support the recommendation that persons 
      handling or using weapons maintenance materials should protect their skin from 
      repeated contact by wearing appropriate personal protective equipment.
FAU - Arfsten, D P
AU  - Arfsten DP
AD  - Naval Health Research Center Detachment, Environmental Health Effects Laboratory, 
      Wright Patterson AFB, OH, USA. darfsten@dlj0ndsl.med.navy.mil
FAU - Azadi, S
AU  - Azadi S
FAU - Butterworth, L F
AU  - Butterworth LF
FAU - Meade, B J
AU  - Meade BJ
LA  - eng
GR  - Y1-ES-0001-03/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Cutan Ocul Toxicol
JT  - Cutaneous and ocular toxicology
JID - 101266892
RN  - 0 (Break-Free CLP)
RN  - 0 (Irritants)
RN  - 0 (Oils)
RN  - 8002-74-2 (Paraffin)
SB  - IM
MH  - Animals
MH  - Dermatitis, Contact/*etiology/pathology
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Gloves, Protective
MH  - Irritants/*toxicity
MH  - Local Lymph Node Assay
MH  - Lymph Nodes/drug effects/immunology
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Naval Medicine
MH  - Oils/*toxicity
MH  - Paraffin/*toxicity
MH  - Skin/*drug effects/pathology
EDAT- 2006/09/19 09:00
MHDA- 2006/12/19 09:00
CRDT- 2006/09/19 09:00
PHST- 2006/09/19 09:00 [pubmed]
PHST- 2006/12/19 09:00 [medline]
PHST- 2006/09/19 09:00 [entrez]
AID - P0N7745559201271 [pii]
AID - 10.1080/15569520600860306 [doi]
PST - ppublish
SO  - Cutan Ocul Toxicol. 2006;25(3):185-94. doi: 10.1080/15569520600860306.