PMID- 1698025
OWN - NLM
STAT- MEDLINE
DCOM- 19901012
LR  - 20181113
IS  - 0002-9440 (Print)
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 137
IP  - 3
DP  - 1990 Sep
TI  - Cellular immune response in multiple sclerosis plaques.
PG  - 575-84
AB  - Multiple sclerosis plaques were immunohistochemically stained to exhibit cells 
      expressing immune-system antigens. Human leukocyte antigen (HLA)-DR-positive 
      cells formed dense rings around all plaque regions. The majority were reactive 
      microglia/macrophages. Counterstaining with oil red O revealed heavy myelin 
      debris within these cells. They were distinct from astrocytes, which were 
      identified with an antibody to glial fibrillary acidic protein (GFAP) and which 
      did not contain oil red O myelin debris. Numerous leukocytes and microglia were 
      stained with antibody to leukocyte common antigen (LCA). Lymphocytes in cuffs 
      around vessels, along the margins of capillary walls, and, sparingly, in the 
      tissue matrix of affected areas, were stained with antibodies to CD4 
      (T-helper/inducer) and CD8 (T-cytotoxic/suppressor). In experimental allergic 
      encephalomyelitis (EAE) induced in Lewis rats, a similar proliferation of 
      Ia-positive (OX6, OX17) cells displaying reactive microglia/macrophage morphology 
      was observed. These Ia-positive cells also were easily distinguished from 
      GFAP-positive astrocytes. The results suggest that macrophages/reactive 
      microglia, and not astrocytes, express class II MHC antigens in multiple 
      sclerosis and EAE plaques.
FAU - Boyle, E A
AU  - Boyle EA
AD  - Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University 
      of British Columbia, Vancouver.
FAU - McGeer, P L
AU  - McGeer PL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (CD4 Antigens)
RN  - 0 (CD8 Antigens)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal
MH  - Antigens, Differentiation, T-Lymphocyte/analysis/immunology
MH  - B-Lymphocytes/pathology
MH  - CD4 Antigens/analysis/immunology
MH  - CD8 Antigens
MH  - Glial Fibrillary Acidic Protein/analysis/immunology
MH  - HLA-DR Antigens/analysis/immunology
MH  - Immunity, Cellular
MH  - Immunoenzyme Techniques
MH  - Multiple Sclerosis/*immunology/pathology
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Staining and Labeling
MH  - T-Lymphocytes/pathology
PMC - PMC1877509
EDAT- 1990/09/01 00:00
MHDA- 1990/09/01 00:01
PMCR- 1991/03/01
CRDT- 1990/09/01 00:00
PHST- 1990/09/01 00:00 [pubmed]
PHST- 1990/09/01 00:01 [medline]
PHST- 1990/09/01 00:00 [entrez]
PHST- 1991/03/01 00:00 [pmc-release]
PST - ppublish
SO  - Am J Pathol. 1990 Sep;137(3):575-84.