PMID- 16980336
OWN - NLM
STAT- MEDLINE
DCOM- 20070125
LR  - 20181113
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Print)
IS  - 0022-3050 (Linking)
VI  - 78
IP  - 2
DP  - 2007 Feb
TI  - The effect of the apolipoprotein E gene polymorphisms and haplotypes on 
      behavioural and psychological symptoms in probable Alzheimer's disease.
PG  - 123-6
AB  - BACKGROUND: Patients with Alzheimer's disease and dementia commonly suffer from 
      behavioural and psychological symptoms of dementia (BPSD). A genetic component to 
      BPSD development in Alzheimer's disease has been demonstrated. Several studies 
      have investigated whether the exon 4 epsilon2/epsilon3/epsilon4 haplotype of the 
      apolipoprotein E (APOE) gene is associated with BPSD, with variable results. 
      OBJECTIVE: We investigated the exon 4 polymorphisms and extended this study to 
      include promoter polymorphisms and the resultant haplotypes across the gene. 
      METHODS: Our large independent cohort of 388 patients with longitudinal measures 
      of BPSD assessed by the Neuropsychiatric Inventory was used to analyse whether 
      any of these variants were associated with the presence of BPSD. RESULTS: We 
      revealed several significant relationships before correction for multiple 
      testing. The exon 4 haplotype was associated with hallucinations and anxiety, 
      A-491T with irritability, T-427C with agitation/aggression and appetite 
      disturbances, and T-219C with depression. Haplotype analyses of all variants did 
      not reveal any statistically significant findings. CONCLUSIONS: Our data and a 
      review of previous studies showed a diversity of relationships, suggesting that 
      these findings might be due to chance and so collectively do not support a role 
      for the APOE gene in BPSD.
FAU - Pritchard, A L
AU  - Pritchard AL
AD  - Molecular Psychiatry Group, Institute of Biomedical Research, University of 
      Birmingham, Birmingham, UK. antonia.pritchard@qimr.edu.au
FAU - Harris, J
AU  - Harris J
FAU - Pritchard, C W
AU  - Pritchard CW
FAU - Coates, J
AU  - Coates J
FAU - Haque, S
AU  - Haque S
FAU - Holder, R
AU  - Holder R
FAU - Bentham, P
AU  - Bentham P
FAU - Lendon, C L
AU  - Lendon CL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060915
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
RN  - 0 (Apolipoprotein E4)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aggression
MH  - Alzheimer Disease/complications/*genetics/*psychology
MH  - Anxiety/genetics
MH  - Apolipoprotein E4/*genetics
MH  - Depression/genetics
MH  - Female
MH  - Hallucinations/genetics
MH  - Haplotypes
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
PMC - PMC2077651
COIS- Competing interests: None declared.
EDAT- 2006/09/19 09:00
MHDA- 2007/01/26 09:00
PMCR- 2010/02/01
CRDT- 2006/09/19 09:00
PHST- 2006/09/19 09:00 [pubmed]
PHST- 2007/01/26 09:00 [medline]
PHST- 2006/09/19 09:00 [entrez]
PHST- 2010/02/01 00:00 [pmc-release]
AID - jnnp.2006.092122 [pii]
AID - jn92122 [pii]
AID - 10.1136/jnnp.2006.092122 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 2007 Feb;78(2):123-6. doi: 
      10.1136/jnnp.2006.092122. Epub 2006 Sep 15.