PMID- 16981842
OWN - NLM
STAT- MEDLINE
DCOM- 20061108
LR  - 20221207
IS  - 1462-2416 (Print)
IS  - 1462-2416 (Linking)
VI  - 7
IP  - 6
DP  - 2006 Sep
TI  - HLA-B locus in Caucasian patients with carbamazepine hypersensitivity.
PG  - 813-8
AB  - BACKGROUND: A strong pharmacogenetic association has been reported in Chinese 
      patients between human leukocyte antigen (HLA)-B*1502 and carbamazepine 
      (CBZ)-induced Stevens-Johnson syndrome (SJS). METHODS: We have genotyped the 
      HLA-B alleles in 56 Caucasian patients with varying severities of CBZ 
      hypersensitivity and 43 controls on CBZ without adverse effects. RESULTS: None of 
      our patients (including two with blistering skin rashes) were positive for the 
      HLA-B*1502 allele. HLA-B*0702 allele may protect against severe CBZ 
      hypersensitivity but warrants further study. Of secondary interest, the 
      correlation between HLA-B*0801 and HLA-DR3, DQ2 and TNF -308 alleles (on the 
      ancestral haplotype 8.1) is consistent with our previous findings. CONCLUSION: 
      HLA-B*1502 does not seem to be a marker for all forms of CBZ-induced 
      hypersensitivity in a Caucasian population.
FAU - Alfirevic, Ana
AU  - Alfirevic A
AD  - Department of Pharmacology & Therapeutics, The University of Liverpool, 
      Sherrington Building, Ashton Street, Liverpool, L69 3GE, UK.
FAU - Jorgensen, Andrea L
AU  - Jorgensen AL
FAU - Williamson, Paula R
AU  - Williamson PR
FAU - Chadwick, David W
AU  - Chadwick DW
FAU - Park, B Kevin
AU  - Park BK
FAU - Pirmohamed, Munir
AU  - Pirmohamed M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pharmacogenomics
JT  - Pharmacogenomics
JID - 100897350
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B*07:02 antigen)
RN  - 0 (HLA-B*08:01 antigen)
RN  - 0 (HLA-B*15:02 antigen)
RN  - 0 (HLA-B15 Antigen)
RN  - 0 (HLA-B7 Antigen)
RN  - 0 (HLA-B8 Antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DR3 Antigen)
RN  - 33CM23913M (Carbamazepine)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - Carbamazepine/*adverse effects
MH  - Case-Control Studies
MH  - Drug Hypersensitivity/*genetics/*immunology
MH  - Gene Frequency
MH  - Genetic Markers
MH  - HLA-B Antigens/*genetics
MH  - HLA-B15 Antigen
MH  - HLA-B7 Antigen
MH  - HLA-B8 Antigen
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DR3 Antigen/genetics
MH  - Humans
MH  - Toxicogenetics
MH  - United Kingdom
MH  - White People/genetics
EDAT- 2006/09/20 09:00
MHDA- 2006/11/10 09:00
CRDT- 2006/09/20 09:00
PHST- 2006/09/20 09:00 [pubmed]
PHST- 2006/11/10 09:00 [medline]
PHST- 2006/09/20 09:00 [entrez]
AID - 10.2217/14622416.7.6.813 [doi]
PST - ppublish
SO  - Pharmacogenomics. 2006 Sep;7(6):813-8. doi: 10.2217/14622416.7.6.813.