PMID- 16982540
OWN - NLM
STAT- MEDLINE
DCOM- 20070216
LR  - 20220321
IS  - 0284-186X (Print)
IS  - 0284-186X (Linking)
VI  - 45
IP  - 7
DP  - 2006
TI  - Accreditation and quality assurance for Radiation Therapy Oncology Group: 
      Multicenter clinical trials using Stereotactic Body Radiation Therapy in lung 
      cancer.
PG  - 779-86
AB  - Starting in 2002, the Radiation Therapy Oncology Group in North America began the 
      process of developing multicenter prospective trials in lung cancer using 
      Stereotactic Body Radiation Therapy (SBRT). Much of the work was based on the 
      prospective single institution trials from Indiana University that had been 
      presented and published. In late 2004, RTOG 0236 using SBRT for medically 
      inoperable patients with clinical stage I non-small cell lung cancer (NSCLC) was 
      activated for accrual. Prior to activation, representatives from the Lung, 
      Image-Guided Therapy, Physics, and Radiobiology Committees met on regular 
      occasions to design the multicenter study and quality assurance measures. SBRT is 
      not a black box, and the essence of the therapy had to be distilled via 
      guidelines. Issues related to patient selection, method of dosimetry 
      construction, equipment requirements, motion assessments and control, site 
      accreditation, data exchange, and follow-up policies were worked out by 
      compromise and consensus. RTOG 0236 has nearly completed its accrual. The Lung 
      Committee has initiated the development of several other trials, each building on 
      the last, to investigate the therapy in central tumors, in combinations with 
      systemic therapy, in operable patients, and in lung metastases patients. The 
      guidelines developed for RTOG 0236 will be refined to take advantage of more 
      modern innovations including heterogeneity corrections and intensity modulation 
      when appropriate. The development of RTOG 0618 using SBRT in operable patients 
      with early stage NSCLC is a testament to both the enthusiasm from already 
      published works and prospective multicenter clinical testing using SBRT 
      techniques.
FAU - Timmerman, Robert
AU  - Timmerman R
AD  - Department of Radiation Oncology, The University of Texas Southwestern Medical 
      Center, Dallas, TX 75390-9183, USA. robert.timmerman@utsouthwestern.edu
FAU - Galvin, James
AU  - Galvin J
FAU - Michalski, Jeff
AU  - Michalski J
FAU - Straube, William
AU  - Straube W
FAU - Ibbott, Geoffrey
AU  - Ibbott G
FAU - Martin, Elizabeth
AU  - Martin E
FAU - Abdulrahman, Ramzi
AU  - Abdulrahman R
FAU - Swann, Suzanne
AU  - Swann S
FAU - Fowler, Jack
AU  - Fowler J
FAU - Choy, Hak
AU  - Choy H
LA  - eng
GR  - 5R21CA097721-02/CA/NCI NIH HHS/United States
GR  - U24 CA 8164/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - Sweden
TA  - Acta Oncol
JT  - Acta oncologica (Stockholm, Sweden)
JID - 8709065
SB  - IM
MH  - Accreditation/*organization & administration
MH  - Carcinoma/pathology/*surgery
MH  - *Clinical Trials as Topic/methods
MH  - Humans
MH  - Lung Neoplasms/pathology/*surgery
MH  - Motion
MH  - *Multicenter Studies as Topic/methods
MH  - Phantoms, Imaging
MH  - Quality Assurance, Health Care/*organization & administration
MH  - Radiation Dosage
MH  - Radiation Oncology/*organization & administration
MH  - Radiometry
MH  - Radiosurgery/*methods
MH  - Radiotherapy/methods
RF  - 17
EDAT- 2006/09/20 09:00
MHDA- 2007/02/17 09:00
CRDT- 2006/09/20 09:00
PHST- 2006/09/20 09:00 [pubmed]
PHST- 2007/02/17 09:00 [medline]
PHST- 2006/09/20 09:00 [entrez]
AID - Q01Q482465N04721 [pii]
AID - 10.1080/02841860600902213 [doi]
PST - ppublish
SO  - Acta Oncol. 2006;45(7):779-86. doi: 10.1080/02841860600902213.