PMID- 16983185
OWN - NLM
STAT- MEDLINE
DCOM- 20070215
LR  - 20220408
IS  - 1420-8008 (Print)
IS  - 1420-8008 (Linking)
VI  - 22
IP  - 5-6
DP  - 2006
TI  - Behavioural and psychological symptoms of Alzheimer type dementia are not 
      correlated with plasma homocysteine concentration.
PG  - 432-8
AB  - BACKGROUND/AIMS: Vitamin B12 and folate deficiencies have been associated with 
      cognitive impairment and various psychiatric symptoms but not specifically with 
      behavioural and psychological symptoms of dementia (BPSD). A limitation of 
      previous studies in dementia was lack of concurrent homocysteine measurement 
      especially as it may provide a better indicator of tissue activities of these 
      vitamins. This study was designed to clarify whether a relationship exists 
      between plasma homocysteine concentration and BPSD. METHODS: Plasma homocysteine, 
      serum vitamin B12 and folate were measured in 23 Alzheimer's disease (AD) 
      patients with BPSD and 27 AD patients without BPSD as determined through the use 
      of the Neuropsychiatric Inventory (NPI). Blood levels of measured substances were 
      also correlated with individual NPI scores and with cumulative NPI scores for 
      different cluster of symptoms. RESULTS: There was no significant difference (p = 
      0.956) in the mean plasma homocysteine levels between AD patients with BPSD 
      (17.48 micromol/l) and AD patients without BPSD (17.34 micromol/l). Similarly, 
      there was no significant difference between the two groups in the mean serum B12 
      (382.61 and 391.60 pg/ml, respectively) and folate (7.95 and 10.02 ng/ml, 
      respectively). Mean levels for both vitamins were well within the laboratory 
      reference range. Neither individual nor cluster NPI scores correlated 
      significantly with plasma homocysteine. CONCLUSION: This study shows for the 
      first time that BPSD are not associated with hyperhomocysteinaemia in Alzheimer 
      dementia. Although previous studies have identified homocysteine as an 
      independent risk factor in AD, the results reported here do not lend weight to an 
      aetiological role for homocysteine specifically in BPSD.
FAU - Tabet, N
AU  - Tabet N
AD  - Postgraduate Medical School, Faculty of Health, University of Brighton, Brighton, 
      UK. n.t.tabet@brighton.ac.uk
FAU - Rafi, H
AU  - Rafi H
FAU - Weaving, G
AU  - Weaving G
FAU - Lyons, B
AU  - Lyons B
FAU - Iversen, S A
AU  - Iversen SA
LA  - eng
PT  - Journal Article
DEP - 20060915
PL  - Switzerland
TA  - Dement Geriatr Cogn Disord
JT  - Dementia and geriatric cognitive disorders
JID - 9705200
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*blood/diagnosis/*psychology
MH  - Female
MH  - Folic Acid/blood
MH  - Homocysteine/*blood
MH  - Humans
MH  - Male
MH  - Mental Disorders/diagnosis/*etiology/*psychology
MH  - Neuropsychological Tests
MH  - Psychological Tests
MH  - Severity of Illness Index
MH  - Vitamin B 12/blood
EDAT- 2006/09/20 09:00
MHDA- 2007/02/16 09:00
CRDT- 2006/09/20 09:00
PHST- 2006/04/20 00:00 [accepted]
PHST- 2006/09/20 09:00 [pubmed]
PHST- 2007/02/16 09:00 [medline]
PHST- 2006/09/20 09:00 [entrez]
AID - 95802 [pii]
AID - 10.1159/000095802 [doi]
PST - ppublish
SO  - Dement Geriatr Cogn Disord. 2006;22(5-6):432-8. doi: 10.1159/000095802. Epub 2006 
      Sep 15.