PMID- 16983643
OWN - NLM
STAT- MEDLINE
DCOM- 20070130
LR  - 20231213
IS  - 0887-4476 (Print)
IS  - 0887-4476 (Linking)
VI  - 60
IP  - 8
DP  - 2006 Dec 15
TI  - Prenatal GABAB1 and GABAB2 receptors: cellular and subcellular organelle 
      localization in early fetal rat cortical neurons.
PG  - 557-66
AB  - Gamma-aminobutyric acid (GABA)(B) receptors appear to influence developmental 
      events, depending on whether they are found at a synapse or in extrasynaptic 
      areas. Little, if anything, is known as to the cellular and subcellular 
      localization of GABA(B1) and GABA(B2) receptors during early fetal development. 
      We used Western blots, immunohistochemistry, and postembedding 
      immunoelectronmicroscopy to investigate fetal rat brain expression and 
      distribution of these receptor proteins. GABA(B1) is expressed as early as 
      gestational day (GD) 11.5 and 12.5, with immunoreactivity found in the all 
      neuroepithelium, and a high expression in the mantel zone and the cortical area's 
      plate; no immunolabeling for GABA(B2) receptor was observed. Our immunogold 
      studies define a pattern of early GABA(B1) receptor protein in dendrite 
      processes, endoplasmic reticulum, and axon terminals of the cortical 
      neuroepithelium on GD 11.5. On GD 12.5, GABA(B1) receptor immunogold was found in 
      dendrite processes, spines and tree, axon terminals, mitochondria, and 
      intracellular organelles of the cortical neuroepithelium. No synapse formation 
      was apparent as no synaptophysin could be found on either GD 11.5 or 12.5. We 
      suggest that GABA(B1) has a functional role in the early fetal brain during 
      neuronal proliferation and migration, and that it is different from the 
      established functional GABA(B) receptor.
FAU - Li, S P
AU  - Li SP
AD  - Division of Life Science, College of Natural Sciences and Applied Life Science 
      (Brain Korea 21), Gyeongsang National University, Chinju 660-701, South Korea.
FAU - Lee, H Y
AU  - Lee HY
FAU - Park, M S
AU  - Park MS
FAU - Bahk, J Y
AU  - Bahk JY
FAU - Chung, B C
AU  - Chung BC
FAU - Kim, M O
AU  - Kim MO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 0 (Gabrb2 protein, rat)
RN  - 0 (Receptors, GABA-A)
RN  - 0 (Receptors, GABA-B)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/*physiology
MH  - Cell Movement/physiology
MH  - Cell Proliferation
MH  - Cerebral Cortex/*embryology/*metabolism/ultrastructure
MH  - Dendrites/metabolism/ultrastructure
MH  - Endoplasmic Reticulum/metabolism/ultrastructure
MH  - Female
MH  - Male
MH  - Microscopy, Immunoelectron
MH  - Mitochondria/metabolism/ultrastructure
MH  - Neurons/*metabolism/ultrastructure
MH  - Organelles/*ultrastructure
MH  - Presynaptic Terminals/metabolism/ultrastructure
MH  - Rats
MH  - Receptors, GABA-A/metabolism
MH  - Receptors, GABA-B/*metabolism
MH  - Stem Cells/metabolism/ultrastructure
MH  - Synaptic Transmission/physiology
MH  - gamma-Aminobutyric Acid/metabolism
EDAT- 2006/09/20 09:00
MHDA- 2007/01/31 09:00
CRDT- 2006/09/20 09:00
PHST- 2006/09/20 09:00 [pubmed]
PHST- 2007/01/31 09:00 [medline]
PHST- 2006/09/20 09:00 [entrez]
AID - 10.1002/syn.20332 [doi]
PST - ppublish
SO  - Synapse. 2006 Dec 15;60(8):557-66. doi: 10.1002/syn.20332.