PMID- 16987381
OWN - NLM
STAT- MEDLINE
DCOM- 20070221
LR  - 20071115
IS  - 1540-8167 (Electronic)
IS  - 1045-3873 (Linking)
VI  - 17
IP  - 12
DP  - 2006 Dec
TI  - Effect of cardiac resynchronization therapy in patients with moderate left 
      ventricular systolic dysfunction and wide QRS complex: a prospective study.
PG  - 1288-92
AB  - BACKGROUND: We sought to investigate the effect of cardiac resynchronization 
      therapy (CRT) on disease progression in patients with moderate left ventricular 
      (LV) systolic dysfunction. METHODS AND RESULTS: This is a prospective study to 
      explore the effect of CRT in 15 optimally treated patients (age: 66.1 +/- 12.8 
      years; male = 13) with New York Heart Association (NYHA) class III, LV ejection 
      fraction >35% and <45% and QRS duration >120 msec. Echocardiographic examination 
      and standard heart failure assessment was performed before and 3 months after CRT 
      implantation. The magnitude of echocardiographic remodeling measurements was 
      compared with 30 age, sex, NYHA class, and heart failure etiology matched 
      patients with conventional CRT indication. There were significant reductions in 
      LV end-systolic (86.2 +/- 24.1 to 69.7 +/- 22.2 mL, P < 0.01)/end-diastolic 
      (135.5 +/- 36.8 to 120.5 +/- 34.6 mL, P < 0.01) volumes, improvement in LV 
      ejection fraction (39.1 +/- 2.2 to 44.2 +/- 5.5%, P = 0.01), and NYHA class (3.0 
      +/- 0.0 to 2.07 +/- 0.46, P < 0.001). There was no difference in changes in LV 
      volumes, ejection fraction, NYHA class, and exercise capacity before and after 
      CRT between the study and conventional groups except for greater improvement in 
      the quality of life score in the conventional group. CONCLUSION: In this 
      prospective study, significant LV reverse remodeling by CRT in those with a wide 
      QRS complex and moderate LV systolic dysfunction was observed. Further studies to 
      explore the benefit of CRT in patients with less severe heart failure are 
      recommended.
FAU - Fung, Jeffrey W H
AU  - Fung JW
AD  - Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales 
      Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China. 
      jwhfung@cuhk.edu.hk
FAU - Zhang, Q
AU  - Zhang Q
FAU - Yip, Gabriel W K
AU  - Yip GW
FAU - Chan, Joseph Y S
AU  - Chan JY
FAU - Chan, Hamish C K
AU  - Chan HC
FAU - Yu, Cheuk M
AU  - Yu CM
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20060920
PL  - United States
TA  - J Cardiovasc Electrophysiol
JT  - Journal of cardiovascular electrophysiology
JID - 9010756
SB  - IM
CIN - J Cardiovasc Electrophysiol. 2006 Dec;17(12):1293-4. PMID: 17096655
MH  - Aged
MH  - Arrhythmias, Cardiac/diagnosis/*etiology/*prevention & control
MH  - Cardiac Pacing, Artificial/*methods
MH  - Female
MH  - Heart Failure/diagnosis/*etiology/*prevention & control
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/*complications/diagnosis/*therapy
EDAT- 2006/09/22 09:00
MHDA- 2007/02/22 09:00
CRDT- 2006/09/22 09:00
PHST- 2006/09/22 09:00 [pubmed]
PHST- 2007/02/22 09:00 [medline]
PHST- 2006/09/22 09:00 [entrez]
AID - JCE612 [pii]
AID - 10.1111/j.1540-8167.2006.00612.x [doi]
PST - ppublish
SO  - J Cardiovasc Electrophysiol. 2006 Dec;17(12):1288-92. doi: 
      10.1111/j.1540-8167.2006.00612.x. Epub 2006 Sep 20.